1、Competitive Inhibition,Succinate,Glutarate,Malonate,Oxalate,Succinate Dehydrogenase,Substrate,Competitive Inhibitor,Product,Adapted from Kleinsmith & Kish (1995) Principles of Cell and Molecular Biology (2e) p.49,Sulfa Drug Is Competitive Inhibitor,Precursor,Folicacid,Tetrahydro-folic acid,Sulfanila
2、mideSulfa drug (anti-inflammation),Para-aminobenzoic acid (PABA),Bacteria needs PABA for the biosynthesis of folic acid,Sulfa drugs has similar structure with PABA, andinhibit bacteria growth.,Adapted from Bohinski (1987) Modern Concepts in Biochemistry (5e) p.197,Domagk (1939),Enzyme Inhibitors Are
3、 Extensively Used, Sulfa drug (anti-inflammation),Pseudo substrate competitive inhibitor, Protease inhibitor,Plaques in brain contains protein inhibitor, HIV protease is critical to life cycle of HIV,HIV protease (homodimer):,inhibitor is used to treat AIDS,Symmetry,Notsymmetry, Human aspartyl protease:(monodimer),Juang RH (2004) BCbasics,Alzheimers disease,HIV protease vs Aspartyl protease,Asymmetric monomer, HIV protease (homodimer),HIV Protease inhibitor is used in treating AIDS,Symmetricdimer,Aspartyl protease (monomer),Juang RH (2004) BCbasics,
