1、更多医学精品 尽在医学吧,http:/ differentiation of nave T cells to Th cells. Depending on the adjuvanticity of the substances co-exposed with the antigen and status of the cells and cytokines in the microenvironment, nave T cells can differentiate into Th1, Th2, Th9, Th17, and Th22.,Role of Th1 and Th2 cells, a
2、nd cytokines in the regulation of cellular and humoral immunity.,Th1/Th2 profile in our hospital,IL-2, IL-4, IL-6, IL-10, TNF-a and IFN-r in the sera.the cytometric bead assay (CBA) Human Th1/Th2 Cytokine kit II (BD Biosciences, San Jose, CA, USA).,Results from current data,During infection and infe
3、ction controlled,The median levels of IL-4, IL-6, IL-10, TNF-a and IFN-r in febrile patients before antibiotic therapy were 3.9, 660.1, 122.7, 6.9 and 11.4 pg/mL, respectively. The interval between the two detections was 5.5 (224) days.Returned to 3.3, 22.8, 9.6, 4.1 and 6.4 pg/mL, respectively, aft
4、er infection was controlled.,Between the G+ and G Bacterial Sepsis,IL-6, IL-10, and TNF-a levels in patients with G bacterial infection were higher than those in patients with G+ bacterial infection. The IL-6, IL-10, and TNF-a of G group were 525.4 (10.2 to 5,000), 96.0 (7.0 to 5,000), and 6.9 (2.54
5、263.4) pg/ml, respectively, which were all significantly higher than those of G+ group (150.0 (8.5 to 5000), 22.6 (3.42813.7), and 4.5 (2.581.6) pg/ml (P0.05).,In Hemophagocytic Lymphohistiocytosis (HLH),In HLH patients, IFN-r and IL-10 levels were significantly elevated and IL-6 levels were moderat
6、ely elevated,but in MDI patients, IL-6 levels were much higher (usually 1000.0 pg/mL) than in HLH patients (60/145 (41.4%) vs. 2/43 (4.7%); p 1000.0 pg/mL) was significantly higher than that (17/145 cases (11.7%); p 0.05) in MDI patients.,The IFN-r levels in the EBV and CMV infection groups were sli
7、ghtly higher than those in the bacterial infectious group, but no significant differences were identified statistically (p 0.05).IFN-r levels were only slightly increased in MDI patients, being rarely more than 100.0 pg/mL (8/145 (5.5%) vs. 39/43 (90.7%) in HLH patients; p 0.001).,Between septic sho
8、ck and non-shock,In septic shock, the IL-2, IL-4, IL-6, IL-10, TNF-a and IFN-r levels were 3.2 (2.3150.1), 4.7 (2.354.9), 2430.6(155.05000), 418.9 (27.85000), 6.5 (3.32140.7) and 10.5 (2.7394.9) pg/mL, respectively; these levels were significantly higher than those (3.0 (1.013.5), 3.5 (1.039.3), 98.
9、4(3.85000), 20.4 (3.45000), 4.5 (1.74263.4) and 10.1(1.8834.1) pg/mL, respectively) (p 0.001) in the febrile episodes without septic shock.,When the IL-6 levels exceeded the maximum detection limits (5000 pg/mL),the IL-10 levels exceeded 1000.0 pg/mL. The IL-6 and IL-10 levels were positively associ
10、ated with septic shock and mortality rates.the neutropenia subgroup and the non-neutropenia subgroup had comparable cytokine levels (p 0.05), indicating that the absolute neutrophil (ANC) count did not affect the cytokine levels.,Cutoff values of 40.6 pg/mL for IL-6, 20.0 pg/mL for IL-10 and 4.2 pg/
11、mL for TNF-a might be important parameters for distinguishing patients with a high probability of having a bacterial infection from those with a low probability.To judge a severe infection, the cut-off values of IL-6, IL-10 and TNF-a can be set at 227.7, 42.0 and 4.6 pg/mL, respectively.,Further study,Tang et al. Clinical Microbiology and Infection 2011;17(11):1666-1673.Tang et al. Pediatr Blood Cancer 2012; 58:5054.,谢 谢 ！,
