1、血糖控制的 “ 个性化 ” 治疗 优泌乐 全线产品支持个体化治疗This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the sys
2、tem are AT89C51 microcontroller and DS18B20 temperature sensor.2010年， CDS修订中国 2型糖尿病防治指南。2007 2010中国 2型糖尿病防治指南 与时俱进 !This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temp
3、erature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor. 新指南适当 放宽 控制目标： HbA1c7.5%则退出研究 )研究分两个阶段This paper mainly introduces the design of an intelligent temperature control system which realizes the function o
4、f temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.-2-1.6-1.2-1.7-1.5-1.8-1.7GL QD+OADLM25 BID+OAD终末时HbA1c自基线变化值(%)*p7.0% ，并且较末次7.0% 的
5、 HbA1C值的增加 0.4% ）次要目标： 每次随访的 HbA1C值 体重变化 日胰岛素使用量 低血糖发生率和发作次数Diabetes Care 34:249255, 2011This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and
6、single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.次要终点：每次随访时的 HbA1c*P10GLGLM25*This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control
7、 by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.比较维持达标与不能维持达标两组人群的基线特征LM25 GL维持达标 没有维持达标 P值 维持达标 没有维持达标 P值基线特征年龄（岁）59.59.17 58.19.1 0.353 57.58.2 57.49.9 0.905男性（）111(5
8、5.0) 134(49.4) 0.308 81(55.1) 154(56.6) 0.331种族 0.311 0.199高加索人 158(78.2) 189(69.7) 118(80.3) 188(69.1)非洲后裔 11(5.4) 13(4.8) 6(4.1) 17(6.3)亚裔 10(5.0) 28(10.3) 7(4.8) 34(12.5)西班牙裔 21(10.4) 31(11.4) 13(8.8) 28(10.3)其他 2(1.0) 10(3.7) 3(2.0) 5(1.8)体重 (kg) 89.719.2 87.818.9 0.794 92.220.5 89.719.9 0.762BM
9、I(kg/m2) 31.65.6 31.75.8 0.266 32.56.0 31.85.6 0.993Diabetes Care 34:249255, 2011This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single c
10、hip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.比较维持达标与不能维持达标两组人群的基线特征LM25 GL维持达标 没有维持达标 P值 维持达标 没有维持达标 P值基线特征病程（年）9.46.2 9.96.4 0.708 8.44.9 9.76.1 0.036HbA1C（）8.51.1 8.81.2 0.043 8.30.9 8.81.1 7.0%,但是自末次 A1C7.0%之后 A1C增值 0.4%Diabetes C
11、are 34:249255, 2011This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C
12、51 microcontroller and DS18B20 temperature sensor.结 论 与甘精胰岛素相比，优泌乐 25组控糖效果更持久，能够维持达标的患者比例高于甘精组 两组低血糖发生情况无差异 维持阶段优泌乐 25组体重增加和甘精组相似 基线 HbA1C水平越低者，达标效果越容易维持； 甘精组患者餐后血糖水平越低者，病程越短者，达标效果越容易维持Diabetes Care 34:249255, 20112型糖尿病患者起始胰岛素治疗方案疗效分析Derived from Sun et al. Curr Med Res Opin 2007; 23:3017-3023数据库回顾性
13、分析美国大规模医学记录回顾研究基础 胰岛素 vs 预混胰岛素This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the syste
14、m are AT89C51 microcontroller and DS18B20 temperature sensor. 18个月，回顾性研究，非随机，临床观察性队列研究 数据来源： GE Electronic Medical Record Database (1998.1-2004.7 2.4 million subjects， ) 8166位起始胰岛素治疗的 2型糖尿病患者 1998 2004年期间，在起始胰岛素治疗之前，至少 12个月以上没有胰岛素使用记录甘精胰岛素(GLG)所有预混胰岛素方案 (CMx)优泌乐 25(LM25)优泌林 70/30(HM70/30)N=3624 N=45
15、42 N=895 N=3647Derived from Sun et al. Curr Med Res Opin 2007; 23:3017-3023研究设计This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chi
16、p microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.研究结果评价 主要观察目标 : HbA1C的降低 : 基础与预混比较 次要观察目标 : HbA1C的降低 : 基础与预混人胰岛素及与预 混胰岛素类似物比较 分析了 4个治疗人群的 HbA1C数据 :GLG - 甘精胰岛素 LM25 - 优泌乐 25 (25% insulin lispro/ 75% ILPS) HM70/30 - 人胰岛素 30/70 (30% human in
17、sulin/70% NPH CMx - 混合预混胰岛素 (人胰岛素及类似物 )Derived from Sun et al. Curr Med Res Opin 2007; 23:3017-3023This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS
18、18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.治疗时间 (月 )Adjusted change in A1C (%)-0.7-0.5-0.3-0.10.1LM25 vs GLGCombined vs GLGHM 30/70 vs GLG3 6 9 12 15 18* *p0.05 与甘精比较美国大规模数据库回顾校正倾向性评分后的 HbA1c变化情况Derived from Sun et al. Curr Med Res Opin 2007; 23:3017-3023PARADIGM 研究2型糖尿病患者启动并强化精蛋白锌赖脯胰岛素混悬液（ LM75/25）的方案不劣于甘精胰岛素加赖脯胰岛素（ G+L）方案预混起始，全程灵动2010年 ADA poster交流
