1、非霍奇金氏淋巴瘤个体化、优化药物治疗研究进展!“!“!$“#!#$#1(%#!#+#!(!,4%$4“#!,!3!“,%!V):!V):!“!#$!%!$!V):$!()$($!$#!V):!R2:!R2:!#!R2:!“#$R2:!R2:!R2:$/Q1!0“(00%$%30!R2:“%#$1*.!R2:/0i!1*.!4+R2!+!+/0i!/0i“$#$_0“$R2:!_0:+EF,.!.)_0“3#$.d2%+$35!“$+).d2%+$!U.d2%+.d2%+3,R2:!.d2%+%!U.d2%+3%“#$.0iR0!R00!“(#)2?;?E:“4#R02%U$+/)!R00!R0
2、0!$R0)-),!R0-),!1“*“R00!“7#$/0V*1(00./)/0i!.0.$3“*.Q+(7.“4+0$%3.+(0R2:+EF,.“!#!+.*+.Q+!.Q+EF,.!“!#$V1“!Q+!0!$.!$!+!Q+“!“#$0G3%R2:!%7.%“.R2“QQ2!$UFM3I%e“$4+75)#,.)!.1$%*)*F:!*)U!$#A!V):#A#!V):%2-%+-!)!$G3%JAH,“V*b,EF:JFM!$G3%Q+!G3%!*QQ2*2,!0W2WK1+$-b$F*+1*“G!,-b$FG!7+1*!1J!G3%$-b$F*+1*G3%!.0i+Q/$G3%_
3、1.!U,.)Q+)G3%U,.)!.1G3%“!%#$g.,!.+$“!Q+)g.,!*,FEFAF:GF:?JAH,“!JAH,“g7%($EF:*EF!JAH,“!2,!G3%$“!3!“4%3!JAH,“!G3%“a)2!UEBC;.,K=AK?AH9E?;FKCD?!UUbR,“#!$“.)UJFM%JAH,“K6K,“!.)G3%!Q+G3%“%.1!.1!“/0i%+EF,.%2,!%.1%QQ2%.0i!JAH,“UQ+%!JAH,“*)3#!“JAH,i)U)/%QQ2%2,!%.1!JAH,i)%JAH,“*)3#!“!.1)U!JAH,i)%JAH,“2,!%/0i%3,
4、*%QQ2#!3$“*,FEF.Q3UJAH,“!JAH,“*,FEF“0V7JAH,“!QQ2%.1%+Q/%2,!“#!#!$“.)!KAH,!%JFL,!.1!.0i%*,FEF%/-0U,.)!KAH,!%G3%!JAH,“%JFM“U)JFM%2,!%QR!QQ2“#A#A!+EF,.!%b3“!3I,b3“#!($“.1*,._/!Q+“U,.)!Q+!“5-/2A=AH9=6E9HF:?+0-.(+0-.,+)b4(B6!+0-.!/0i“*).Q“!.Q“JAH,“)aV!JAH,“)aV“0W2W,)!0W2W,).1*,._/0W2W,)0W2W,“K6E,!K6E+EF,
5、.*,FEF!K6E,!K6E,!/0i#!4$“.1)G3%T0!K6E,!V):.1R0,(!.)R0,(%!%0!R0,0!.)R0,(0!.VW2#!7$“W,/0!/0“V):*,FEF*!(JAH,“)JFM“(3I%(G3%“.VW2*!(G3%“(JAH,“!.VW2.Q“%(2/)+)b“A!V):!“.VW2!)!*2-%+-!0.%R!%“*%!%!V):!%!%#“$!%!“V):!2,LG5#“5!35!U!“!1CJJF#“!$V):!.VW2“VCHH!#“$!9H6C?#“%$!“*WDA90.FG%!“b-00!“B!“!%!V):!%!“!#!$aFK?:W
6、!+EKC;FL?#WN?ENC?O9EF;C9DFHCD6CNC6FHCc?6;?EFG?;CA:;EF;?LC?:9ED9D,96LBCDI:H=KG9KF:#a$#.HCD)=KG9KF!“!%RGGH!(*:3%!3!“4%3!“RFAC6FDFD6FK1#T?C:KFDQ#RAKC6;R.#?;FH#+KFG9KFDL?D9K?:?S?DA?NFECF;C9DA9D;FCDCDL!#$“KCH,HC9D:CDLH?DAH?9;C6?G9H=K9EGC:K:!a“#F;E?#“!#$7$7“4!%“9E?NFWU#EC:FD9NF+d#29:CJH?GE?6CA;C9D9;?,CAC?
7、DA=9A?K9;?EFG=CDGF;C?D;:OC;H=KG9GE9HC?E,F;CN?6C:?F:?:JF:?69D/Q1!L?D?“(0FD6.%$%30G9H=K9EGC:K:!a“#UHH_MGUC9H/?6#“%#!%“$!4%!$“)FN?E6C?E?.#.CF:9DR#.9:;?F-#?;FH#29H=K9EGC:K4+CD;?E?6A?69HF;?AFEEC?EL?D?FD6C;:E?HF;C9D,:CG;9K?;9;E?MF;?GHF:KFH?N?H:FD69;A9K?9ACH6,996FA;?H=KG9JHF:;CAH?B?KCF!a“#UH996#“#!$%4%“!3“
8、/9HCDF,+EAF:/#/FEA?R#CHHFK9E#?;FH#_SCHCJEF,;CN?DAH?9:C6?;EFD:G9E;?E,“%_0“GE9;?CD?MGE?:C9DA9EE?HF;?:OC;?MNCN9:?D:C;CNC;=;9H6FEFJCD?CDAE9D,CAH=KG9A=;CAH?B?KCF%.)A?HH:!a“#)?B?KCF#“3#!7%!$!“+GH?DA1#HF;?H;?ET#.d2%+L?D9;=G?:FD6;E?F;K?D;E?:G9D:?CDGF?6CF;ECAFA;?H=KG9JHF:;CAH?BF?KCF!a“#UEaVF?KF;9H#“!#!“$“$!(
9、“+D6?E?E#RAEFGG?/#UE?AHCD+#?;FH#29H=K9EGC:K:OC;LH;F;C9D?R,;EFD:?EF:?L?D?:FD6CDC;CFHE?:G9D:?;9LHA9A9E;CA9C6:CDACH6996FA;?H=KG9JHF:;CAH?,BF?KCF!a“#2FEKFA9L?D?;CA:#“#!$(!3!4“2?;?E:g#2E?C:H?E,+6FK:R#H;F;C9D?R,;EFD:?EF:?L?,D?;CAG9H=K9EGC:K:FD6CD6CNC6FH:?D:C;CNC;=;9;?9;9,;9MCA?A;9AC:GHF;CD!a“#+D;CAFDA?EQE
10、L:#“#!$%7!7“19HHCD:9DR#)?N?D?+2#/?D:F*b#?;FH#F:;ECAKFE,LCDFHc9D?H=KG9KFC:F:9ACF;?6OC;G9H=K9EGC:K:CDL?D?:CDN9HN?6CDCDHFKKF;9E=E?:G9D:?FD6FD;C9MC6F,;CN?AFGFAC;=!a“#UH996#“%#!“%$!(!“d?d#RFCBFOFb#W;F/#?;FH#+DA;C9DFH:CDLH?,D,AH?9;C6?G9H=K9EGC:KCD;?KFDA=;C6CD?6?FKCDF:?L?D?A9D;ECJ;CDL;9FEF,.:?D:C;CNC;=!a“#
11、2FEKFA9L?D?;,CA:#“%#!%$“7!“*C;cL?EFH6R/#9=FH1b#W:J9ED?T1#?;FH#-6?D;CC,AF;C9D9DA;C9DFH:CDLH?DAH?9;C6?G9H=K9EGC:KFG,H9;=G?:CD;?A=;C6CD?6?FKCDF:?GE9K9;?E!a“#VK?D,?;#“#!7%$“(!“R?N?ECD0#)?9DLU#.F:C6=V#?;FH#9N?HQ+:?,S?DA?NFECFD;:CD;?V1“!Q+E?GFCEL?D?CDEF6C9,:?D:C;CN?AFDA?EGF;C?D;:!a“#-D;a1F6CF;WDA9HUC9H2=:
12、#“!#3$!%“%!%“*FDR#.?ED?=U#1?CD9H6T#?;FH#QC:EG;C9D9G3%DA;C9DCDCKK9E;FHCc?6KFDA?HH:69?:D9;F?A;:E,NCNFH9EFG9G;9:C:F;?E;FM9H9ENCDAEC:;CD?;E?F;K?D;!a“#.HCD.FDA?E1?:#!774#$!$(!$“WI.9DD9E2/#TF:?EKFDDb#1?HF;C9D:CGJ?;O?DQ+AE9:,HCDB:#A?HHA=AH?FD6FG9G;9:C:CDUEBC;I:H=KG9KFA?HHHCD?:6C?ECDLCD:?D:C;CNC;=;9DC;E9L?D
13、K:;FE6!a“#.FDA?E1?:#!77!#3!$33!3“RCK9DCFD2)#ECHH9;Q+#D?c#UAH,“FD6JAH,i)AFD6C?E?D;CFHH=JH9ABA?K9;?EFG=,CD6A?6A?HH6?F;!a“#UH996#!77(#7$!“4!“.CDF;Ha#b9;A?;B9N1#E9:A?HU#?;FH#+cC69;=KC6CD?E?:C:;FDA?9V7KFD0,A?HHH=KG9KFA?HH:C:F:9ACF;,?6OC;6?AE?F:?6:?D:C;CNC;=;9FD;C;K9EFL?D;:FD6CDC,JC;C9D9FG9G;9:C:!a“#-D;a/9H/?6#!774#“$43!(“QK9D;?;.#*FJCFD9O:BF/b#/FD;CDACAQ#?;FH#.9KK9DE?:C:;FDA?K?AFDC:K:;96?9M=DAH?9:C6?FDF,H9L?:CDNFECFD;:9;?KFD?E=;E9H?BF?KCAHCD?b3“!a“#UEaVF?KF;9H#!777#!$(4