1、This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller
2、and DS18B20 temperature sensor.COPD稳定期的治疗 和长效 抗胆碱药物在 COPD治疗中的地位This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer.
3、 The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.主要内容 COPD稳定期的治疗 长效抗胆碱药的药理作用机制 噻托溴铵的临床 应用This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using singl
4、e bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.减轻症状改善健康状况改善运动能力预防疾病进展降低死亡率预防和治疗急性加重减轻症状降低风险远期目标近期目标COPD的治疗 目标 -2013 GOLDThis paper mainly introduces the design of an intelligent temp
5、erature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.COPD的疾病特点为：持续存在的气流受限COPD和哮喘都是慢性
6、气道炎症性疾病，但两者的炎症本质不同哮喘致敏因素哮喘型气道炎症CD4+T淋巴细胞嗜酸粒细胞COPD有害物质COPD型气道炎症CD8+T淋巴细胞中性粒细胞和巨噬细胞可 逆 持续受限 吸入性糖皮质激素为一线用药支气管舒张剂为核心用药COPD的治疗与疾病特点相关This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus
7、digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.激 素吸入优于口服 （ A级证据）长效优于短效 （ A级证据） 联用优于单用，可 2受体激动剂联合抗胆碱能药物 （ B级证据） 支气管舒张剂不推荐长期单一口服或吸入糖皮质激素推荐用于 FEV150%预计值，以及频繁急性加重且长效支气管舒张剂不能很好控制症状 （ A级证据）茶 碱 疗
8、效较差，副作用较多，不推荐茶碱治疗，除非其它长效支气管舒张剂无效或不可获得 （ B级证据 ）支气管舒张剂是控制症状的核心用药GOLD 2013This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microc
9、omputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.稳定期治疗药物分类支气管舒张剂2受体激动剂 SABA沙丁胺醇LABA沙美特罗抗胆碱能药物 SAMA异丙托溴铵LAMA噻托溴铵甲基黄嘌呤类（茶碱等 ）糖皮质激素磷酸二酯酶 -4 抑制剂支气管舒张剂 /激素复方其它按需或 规律使用可预防和减少症状（ A级证据）GOLD 2013This paper mainly introduces the design of an intelligent tem
10、perature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.选择性阻断 M1、 M3受体，持续 24小时扩张气道减少急性
11、加重，降低相关住院风险。改善临床症状和健康状况，促进肺康复并未增加心血管风险，临床使用证实安全，有良好的依从性，无药物耐受POET研究证明噻托溴铵减轻急性加重优于沙美特罗1 2 42013 GOLD 关于 噻托溴铵 的描述3This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperat
12、ure sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor. 噻托溴铵联合 LABA/ICS改善 FEV1和临床症状，提高相关生活质量，减少急性加重风险 联合使用作用机制不同的支气管舒张剂，具有协同作用，提高疗效，降低不良反应。协同作用提高疗效2013 GOLD 关于 噻托溴铵联合用药 的描述This paper mainly introduces the design
13、of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.2013-GOLD
14、 稳定期治疗 吸入糖皮质激素 描述ICS改善症状、肺功能、生活质量、降低 FEV160%患者 急性加重频率对肺部和全身炎症的疗效具有争议，在稳定期 COPD的治疗中的作用局限长期使用 ICS不会改变 FEV1的下降和死亡率长期应用的剂量 -效应关系和安全性尚不清楚停药可能导致一些患者急性加重适应症之外不应长期处方吸入 ICS，因会增加肺炎风险和长期使用有增加骨折风险的可能性This paper mainly introduces the design of an intelligent temperature control system which realizes the function
15、 of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.患者 推荐首选 可选 其他可选A SAMA/SABA LAMA/LABA或 SABA+SAMA 茶碱B LAMA/LABA LAMA+LABA SABA+/SAM
16、A茶碱C LAMA/ICS+LABA LAMA+LABA PDE4抑制剂SABA+/SAMA茶碱D LAMA/ICS+LABAICS+LAMAICS+LABA+LAMA/ICS+LABA+PDE4抑制剂/LAMA+LABA/LAMA+PDE4抑制剂羧甲司坦茶碱SABA+/SAMALAMA+ICS推荐首选 备选LAMA+PDE4抑制剂LABA+PDE4抑制剂羧甲司坦SABA+/SAMA茶碱2013 GOLD更新COPD稳定期 药物 治疗This paper mainly introduces the design of an intelligent temperature control sys
17、tem which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.1 稳定期药物治疗基础用药为支气管舒张剂，吸入制剂优于口服，长效药物优于短效 。噻托溴铵减少急性加重
18、及其引起的住院，改善症状和健康状况，促进肺康复。长期治疗安全性好，降低心血管和呼吸道并发症发生率。ICS只在有指征的患者适用23小结This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomput
19、er. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.主要内容 COPD稳定期的治疗 长效抗胆碱药的药理作用机制 噻托溴铵的临床应用This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using sin
20、gle bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.气道上皮中枢神经系统迷走神经副交感神经节AChAChACh炎症细胞介质粘膜下腺毒蕈碱受体刺激物(如吸烟、细菌、病毒 )气道平滑肌收缩粘液分泌过多气道的胆碱能调节Peter J. Barnes， CHEST 2000; 117:63S 66SThis paper ma
21、inly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 t
22、emperature sensor.M3介导 Ach，使支气管收缩，粘液分泌增多副交感神经节乙酰胆碱直接扩张支气管气道平滑肌烟碱受体 (+)M1-受体 (+)M2-受体 ()M3-受体 (+)M1起信息传递作用，促进胆碱能神经反射，从而引起支气管收缩M2抑制乙酰胆碱释放，使支气管舒张噻托溴铵选择性阻断 M1、M3受体长效抗胆碱药 -噻托溴铵的药理作用 机制Tina Koumis， New Drug， 2005： 27:377-392Peter J. Barnes， CHEST 2000; 117:63S 66SThis paper mainly introduces the design of
23、 an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.COPD病变过程中，气
24、道壁增厚加剧了胆碱能收缩的影响噻托溴铵减少胆碱能收缩This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system ar
25、e AT89C51 microcontroller and DS18B20 temperature sensor. COPD稳定期的治疗 长效抗胆碱药的药理作用机制 噻托溴铵的临床应用主要内容 持续改善肺功能、提高运动耐量 减轻症状、改善生活质量 减少急性加重 一天一次、使用方便、依从性高 降低全因死亡率This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and con
26、trol by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor. 噻 托溴铵治疗 COPD持续改善肺功能提高运动耐量This paper mainly introduces the design of an intelligent temperature control system which
27、 realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.噻托溴铵 30min显著改善 FEV1 噻托溴 铵 (n=356) 第 1天 第 8天 -第 364天 异 丙托溴 铵
28、 (n=179)P0.05首次给药 30min后，显著改善 FEV1治疗 1年， FEV1谷值显著提高，未出现耐受现象用药后时间（分钟）30W. Vincken， Eur Respir J 2002; 19: 209216This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperatu
29、re sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.治疗 1年， 噻托溴铵持续改善 FEV1谷值P0.001 at all time points基线水平T-I=150 mL噻托溴铵（ n=356)异丙托溴铵（ n=179）W. Vincken， Eur Respir J 2002; 19: 209216This paper mainly introduces th
30、e design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.
31、UPLIFT研究n=5993， 4年， 37个国家， 490个中心P0.001Donald P. Tashkin, N Engl J Med 2008;9:1543-1594治疗 4年， 噻托溴铵持续改善肺 功能This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature se
32、nsor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.lStudy 1ln=623, 6个月P0.05两项病例数 600的双模拟 RCT对照研究对比沙美特罗lStudy 2ln=653, 12周噻托溴铵 噻托溴铵噻托溴铵 噻托溴铵相比 LABA， 噻 托溴铵更能改善肺 功能James F. Donohue, CHEST , 2002;122(1):47-55Pulmonary
33、Pharmacology 18(6):397-404This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system ar
34、e AT89C51 microcontroller and DS18B20 temperature sensor.对 11项 RCT研究进行 meta分析u 与异丙托溴铵相比 ，噻托溴铵充分改善 FEV1（平均改善 304ml）及症状u 对于中国稳定期 COPD患者，噻托溴铵应为一线用药对于中国稳定期患者噻托溴铵充分改善肺功能和 症状Respirology， 2009； 5:666-674This paper mainly introduces the design of an intelligent temperature control system which realizes the
35、function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.首日用药 后噻 托溴铵即提高运动耐受时间=228s =236sP=0.002 P0.001 P0.001评价方法： 6分钟步行距离Chest， 2
36、005;128;1168-1178 This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C5
37、1 microcontroller and DS18B20 temperature sensor.噻托溴铵改善 运动耐量增加 步行耐受时间安慰剂（ n=18） 噻托溴铵 (n=18)1天后 21天 后耐受时间（S）150100500-50P=0.017 P0.05运动耐受时间(S)天数噻托溴铵 (n=96)安慰剂 (n=91)71%患者步行耐受时间改善超过65秒评价方法： 6分钟步行距离第 42天，步行耐受时间提高21.4%Eur Respir J 2012 39:265-271;Eur Respir J 2004; 23: 832840This paper mainly introduces
38、 the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sens
39、or. 噻 托溴铵治疗 COPD缓解呼吸困难症状改善健康生活质量This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the sys
40、tem are AT89C51 microcontroller and DS18B20 temperature sensor.SGRQ改善大于 4分比例SGRQ评分异丙托溴铵 噻托溴铵P 0.001P 0.05治疗天数 治疗天数un=553，双盲双模拟 RCT异丙托溴铵噻托溴铵噻托溴铵 显著改善 SGRQ评分 Eur Respir J 2012 39:265-271This paper mainly introduces the design of an intelligent temperature control system which realizes the function of
41、temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor.SGRQ问卷6个月噻托溴铵其它治疗方案差异 P值症状评分持续吸烟者 313 301-6.02（ -8.66- -3.38） 0.0001戒烟者1449 1405-4.09
42、（ -5.46- -2.72) 0.0001活动评分持续吸烟者 308 297-6.17(-8.31-4.03） 0.0001戒烟者1428 2375-2.71（ -3.8-2.71） 0.000148个月噻托溴铵其它治疗方案差异 P值201 192-4.67(-8.4- -0.95) 0.0141067 933-2.15（ -3.94-0.36）0.019207 189 -5.69（ -8.67-2.7） 0.011037 916-3.46（ -4.96-1.96） 0.01u其它治疗方案：安慰剂或合并除抗胆碱药外其它常用支气管扩张剂对于不同吸烟状况患者噻托溴铵更能改善症状与活动 能力Tas
43、hkin, N Engl J Med 2008;9:1543-1594This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the
44、system are AT89C51 microcontroller and DS18B20 temperature sensor.2项安慰剂对照 RCT，观察期 1年， n=921加重频率噻托溴铵（ n=516） 安慰剂（ n=324）N 总分 N 总分0 326 -4.0（ 0.7） 175 -1.5（ 0.9）1 111 -2.7（ 1.1） 92 0.9（ 1.2）2 44 -1.3（ 1.8） 34 2.6（ 2.0） 2 25 -3.4（ 2.0） 23 5.3（ 2.5）P 0.001对于不同加重频率患者噻托溴铵显著改善 SGRQ总分Int J Chron Obstruct Pu
45、lmon Dis， 2009:4 245251This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are A
46、T89C51 microcontroller and DS18B20 temperature sensor.SGRQ改善值肺气肿表型 非肺气肿表型u 评估方法： SGRQ问卷对于不同表型 COPD噻托溴铵 改善症状优于 沙美特罗Int J Chron Obstruct Pulmon Dis， 2011:6 219227This paper mainly introduces the design of an intelligent temperature control system which realizes the function of temperature measurement and control by using single bus digital temperature sensor DS18B20 and single chip microcomputer. The core components of the system are AT89C51 microcontroller and DS18B20 temperature sensor. 噻 托溴铵治疗 COPD降低急性加重风险减少全身激素及抗菌药使用
