1、Uveitis and Systemic Disease,Classification When to investigate ? Common Causes Systemic associations,Uveitis and Systemic Disease,Uveitis,Uveitis, a term correctly used to describe inflammation of the uveal tract (iris, ciliary body, choroid) alone, in reality comprises a large group of diverse dis
2、eases affecting not only the uvea but also the retina, optic nerve and vitreous. Uveitis is a major cause of severe visual impairment and has been estimated to account for 10-15% of all cases of total blindness in the USA. In surveys of the causes of blindness uveitis has usually not been included a
3、nd is probably underestimated,Uveitis and Systemic Disease,Complications from chronic uveitis,Complications from chronic uveitis are common and may result in severe visual loss Macular oedema can complicate any type of uveitis and can cause substantial visual loss. Cataract is common in chronic uvei
4、tis and its treatment with corticosteroids. Techniques for cataract surgery and perioperative management have improved greatly, and most patients with uveitis are now suitable for intraocular lens implantation and do well.18 Glaucoma is the most overlooked complication of chronic uveitis and has sev
5、eral causes.19 Medical management with topical agents such as blockers control the elevation of intraocular pressure in most patients. Some patients also require oral carbonic anhydrase inhibitors, while surgical intervention is reserved for those who have progressive visual loss or uncontrollable i
6、ntraocular,Uveitis and Systemic Disease,Uveitis and Systemic Disease,Uveitis and Systemic Disease,Uveitis and Systemic Disease,Uveitis and Systemic Disease,Uveitis and Systemic Disease,Uveitis and Systemic Disease -History and examination,When to investigate,One of the most pressing questions that a
7、rises in the mind of every ophthalmologist who sees a new case of uveitis is “what is the cause of this disease?“ In evaluating patients with uveitis, the ophthalmologist must consider that a lengthy list of infections, autoimmune systemic diseases, distinctive inflammatory conditions and masquerade
8、 syndromes may all cause uveal inflammation. Despite this array of potential diagnoses, the vast majority of patients have disease that defies categorisation.,Uveitis and Systemic Disease-avoid a shotgun approach to investigation ! Do not wade in like John Wayne !,General Investigations,A recent ret
9、rospective review of patients with various types of uveitis showed the following abnormal results: full blood count: 23/113 (20.3%), plasma viscosity / ESR: 37/108 (34.2%), VDRL/TPHA: 3/70 (4.3%), angiotensin converting enzyme (ACE): 9/77 (10.8%) and chest x-ray (CXR): 15/103 (14.6%). Sarcoidosis wa
10、s diagnosed in eight patients who had an abnormal CXR raised ACE. All patients with symptoms of other organ system dysfunction or general malaise should be investigated to rule out under-lying systemic disease.,Uveitis and Systemic Disease,Uveitis and Systemic Disease,Uveitis and Systemic Disease,HL
11、A-B27 disease.,Debate exists as to whether patients with the commonest type of uveitis (acute anterior uveitis - AAU) should be investigated. It is well recognised that approximately 50% of patients with AAU are HLA-B27 positive. A number of these patients will give a history of an associated HLA-B2
12、7 disease. HLA-B27-associated AAU often presents with a number of clinical clues which help in diagnosis: it is usually recurrent, unilateral but alternating, with severe anterior chamber inflammation (posterior synechiae, fibrin and hypopyon).,Useful investigations for chronic uveitis,Chest x ray D
13、iagnosis of tuberculosis, sarcoidosis, lymphoma, lung carcinoma Syphilis serologyDiagnosis of syphilis HLA-A29Diagnosis of birdshot chorioretinopathy Mantoux testAnergic response despite prior BCG vaccination is consistent with sarcoidosis. Strong positive response without prior vaccination suggests
14、 exposure to tuberculosis HIV serologyIf patient of high risk status or clinical picture suggests HIV related uveitis such as cytomegalovirus retinitis Lyme disease serologyIf patient from endemic area or with history of exposure and suggestive symptoms Antinuclear antibodiesIf clinical picture sugg
15、ests juvenile chronic arthritis ANF ANCA Rhem Factor Aqueous and vitreous biopsiesDiagnosis of infective endophthalmitis and intraocular lymphoma,Uveitis and Systemic Disease,Ankylosing Spondylitis30% of AS patients develop iritis, especially if male; iritis may precede arthritis rarely retinal vasc
16、ulitis / vitritis. Acute anterior uveitis lasting 2-6 weeks, good prognosisInvestigations in suspected ankylosing spondylitis X-ray sacroiliac joints HLA B27 (positive in more than 90% ),Uveitis and Systemic Disease,Associations of Reiters SyndromeOccurs if genetically predisposed (HLA B27); 60 - 90
17、% association MF Exposure to certain urethritis / dysentery organisms: e.g. Chlamydia, Yersinia, Shigella, Salmonella, Campylobacter. The order of manifestation is normally: urethritis conjunctivitis arthritis. Ocular 20% anterior uveitis, 60% conjunctivitis, episcleritis, keratitis, post-uveitis. R
18、eiters disease can sometimes result in hypopyon formation,Uveitis and Systemic Disease,Uveitis and Systemic Disease,Uveitis and Systemic Disease,Sarcoidosis This chronic non-caseating granulomatous systemic disease of unknown aetiology affects women more commonly than men and is more common in indiv
19、iduals of Afro-Caribbean ethnicity. In Britain sarcoidosis is the commonest systemic disease that presents as chronic uveitis. It has protean ocular manifestations and may present with a spectrum of ocular signs, including anterior and posterior uveitis,retinal vascular sheathing, and optic disc abn
20、ormalities Ocular Manifestations About 30% of patients with sarcoidosis have ocular involvement. Iritis may be acute or chronic; it may be unilateral or bilateral. Patients with posterior uveitis usually have anterior uveitis as well. Vitritis is also commonand tends to occur in older patients. Ther
21、e may be retinal periphlebitis; the vessels may display an exudative cuff (so called candle wax drippings). Inflammation of the retina may lead to macularoedema, retinal granuloma, preretinal nodules and retinal haemorrhage. Inflammationof the optic nerve may cause optic disc oedema, granuloma and n
22、eovascularization.Branch retinal vein occlusion and retinal neovascularisation are uncommon,Uveitis and Systemic Disease,Sarciodosis - InvestigationsChest X-raySerum ACE (angiotensin converting enzyme)- this is elevated in active disease urine and serum calcium levels- hypercalciuria is common hyper
23、calcaemia is less commonConjunctival biopsy may show granulomata,Uveitis and Systemic Disease,Uveitis and Systemic Disease,Uveitis and Systemic Disease,Uveitis and Systemic Disease,Uveitis and Systemic Disease,Ocular Manifestations of Tuberculosis Affects 2% of sufferers of active tuberculosis , uve
24、itis is commonest manifestation. Systemic disease is often apparent.Eyelids- lupus vulgaris (nodules surrounded by erythema) Orbit- cellulitis, dacryoadenitis, dacryocystitis, osteomyelitis, abscess Conjunctiva- rarely affected, chronic conjunctivitis Cornea- phlyctenular keratoconjunctivitis, inter
25、stitial keratitis (unilateral, sectorial, superficial vascularisation) Sclera- episcleritis, nodular scleritis Uveitis- chronic granulomatous anterior uveitis, multifocal choroiditis, exudative retinitis, vasculitis, optic nerve oedema, papilloedema,Uveitis and Systemic Disease,Juvenile Chronic Arth
26、ritisChronic AAU , usually bilateral Commoner in female patients, the young, ANF positive. Pauciarticular disease 5 joints.Complications Glaucoma (20%) Cataract (40%) Band Keratopathy (40%),Uveitis and Systemic Disease,Uveitis and Systemic Disease,Uveitis and Systemic Disease,Monitoring Children wit
27、h Juvenile Chronic ArthritisHigh Risk Early Onset , 6 years, Pauciarticular Disease , ANA Positive3 months for first year , then 6 months for five years , then annuallyMedium Riskpolyarticular disease ANA positive , pauciarticular -disease ANA negative6 monthly intervals for 5 years then annuallyLow
28、 RiskSystemic JCA , B27 associated arthritis , disease starting after age 11Duration For ten years after onset of JCA or until age 12, whichever is shorter.Source RCOphth (UK), British Paediatric Association (1994),Masquerade Syndromes,Intraocular lymphoma may present as a chronic uveitis in older p
29、atients, especially when thereis vitritis and vitreous veils and a poor response to treatment. Intraocular tumours, particularly retinoblastoma in children, may also occasionally present in this manner. Differential Diagnosis Of Uveitis- It is of paramount importance to note that uveitis can be caus
30、ed or mimicked by the following-“Masquerade Syndromes”- neoplasms mimicking uveitis Ocular malignant melanoma Retinoblastoma Reticulum Cell Sarcoma ( Primary Intraocular Lymphoma ) Leukaemia Lymphoma Ocular MetastasisOther- Endophthalmitis Retinal detachment Intraocular foreign body,Uveitis and Syst
31、emic Disease,Uveitis and Systemic Disease,Uveitis and Systemic Disease,SyphilisUveitis may be acute or chronic, unilateral or bilateral. Interstitial keratitis affects a small percentage of acquired cases and is often unilateral. Chorioretinitis is bilateral in 50% of cases;multifocal or diffuse yel
32、low exudate is seen.The chorioretinitis may resolve, leaving extensive bone spicule pigmentation. The appearance may resemble retinitis pigmentosa. There may be retinal oedema, haemorrhages, exudates, cotton wool spotsand vascular sheathing. Optic disc oedema may also be seen.Investigations for susp
33、ected syphilitic uveitis include VDRL and FTA-ABS tests. The VDRL test is useful for screening; false positive results may occur. The FTA-ABS test remains positive for life, even after treatment.,Uveitis and Systemic Disease- about 5% of uveitis caused by syphilis in some series,Therapeutics,The aim
34、s of treatment are to control inflammation, prevent visual loss, and minimise long term complications of the disease and its treatment. Macular oedema is the commonest indication for treatment. Treatment is usually indicated if the visual acuity has fallen to less than 6/12, or if the patient is exp
35、eriencing visual difficulties. In patients with longstanding macular oedema and poor vision or where it is not possible to determine easily the cause of visual loss, a trial of immunosuppressive treatment is usually indicated to determine whether the visual loss is reversible. Many patients with uni
36、lateral chronic uveitis can be managed with topical corticosteroids to control anterior uveitis and periocular corticosteroids for macular oedema and visual loss. Patients with useful vision in only one eye must be managed aggressively to control inflammation and preserve vision.,Systemic corticoste
37、roids,Corticosteroids are the mainstay of systemic treatment for patients with chronic uveitis, and the usual indication for treatment is the presence of macular oedema and visual acuity of less than 6/12. Patients should be treated with appropriate doses to determine whether the macular oedema is r
38、eversible. Thus maximum treatment (1.0-1.5 mg/kg body weight/day of prednisone or prednisolone) should be used for two to three weeks. If there is no response at this dose, addition of a second line agent such as cyclosporin (or azathioprine or mycophenolate in older patients) for a further four to
39、six weeks may be considered. In children the doses should be adjusted appropriately.,Other systemic immunosuppressive therapy,If macular oedema recurs and visual acuity decreases at an unacceptably high dose of corticosteroid (15 mg/day of prednisolone) an additional drug is necessary to help contro
40、l the inflammation. Cyclosporin is the drug of choice for most patients aged under 50 years.The commonest dose limiting side effects of cyclosporin are hypertension and renal dysfunction, which are usually reversible if the drug is stopped. Several other drugs can be considered in patients who requi
41、re additional immunosuppressive therapy when cyclosporin is not appropriate or not tolerated. Azathioprine, methotrexate, and, much less commonly, cyclophosphamide are the most used, but each is associated with important side effects and complications. Other agents such as mycophenolate, tacrolimus,
42、 and humanised Tac monoclonal antibodies have been usedThe decision to start treatment with immunosuppressive drugs is a long term commitment by both the clinician and patient, as treatment is likely to last for a minimum of six months and is often much longer.,Surgery,Surgery may be required for co
43、mplications such as cataract, glaucoma, and vitreoretinal problems, but, except in emergency situations, it should be contemplated only once the uveitis is controlled, ideally for at least three months. Intraocular surgery (cataract removal, vitrectomy, and retinal detachment surgery) is performed u
44、nder the cover of systemic corticosteroids to prevent a relapse of uveitis. Removal of the vitreous body (vitrectomy) may be helpful when there is substantial opacity but also may improve disease control, particularly in younger patients.,Complications of chronic uveitis and their management,Macular
45、 oedema Periocular steroids Systemic steroids Immunosuppressive drugs Cataract Surgery once uveitis controlled for 3 months preoperatively Perioperative cover with corticosteroid Intraocular lens in most patients Glaucoma Management depends on type Topical drugs Short term treatment with systemic ca
46、rbonic anhydrase inhibitors Surgery Synechiae Minimise with regular mydriatics Band keratopathy Chelation with EDTA Excimer laser Vitreous opacities Observation Occasionally short course of corticosteroids Vitrectomy rarely required Vitreous haemorrhage Observation Exclude new vessels and retinal te
47、ar as cause Retinal neovascularisation Control uveitis Laser photocoagulation if ischaemia present Subretinal neovascularisation Observation Laser photocoagulation Interferon a Surgical membranectomy Retinal detachment Determine whether exudative, rhegmatogenous, or traction Surgery usually involves
48、 vitrectomy Perioperative cover with corticosteroid,Summary points,Intraocular inflammation has various causes and can be acute or chronic In either case the inflammatory process can be apparently localised to the eye or be part of a systemic disease such as sarcoidosis or Behets disease The inflamm
49、ation can occur in any part of the eyeanterior, posterior, or bothand visual loss can occur with any type Treatment depends on the location and severity of the inflammation, with systemic drugs being reserved for sight threatening posterior disease Complications are common and include cataract, glaucoma, macular oedemaall of which can reduce vision,Uveitis and Systemic Disease,Uveitis and Systemic Disease,
