1、DOI 1013288/j11-2166/r201514002“973”2013CB531703*13901137632“”“”1 1 1*2 2 3 1 1 3 1.1 100091 2.3.、。、。、“”“”“”。“”“”-。1 1.1。1/2。、。1.2 1。Ca2+5.0mmol/L。2、。3。1.3、Ca2+。、Ca2+、Ca2+A TP、Ca2+、Ca2+ES 1。ES UP ES 2 3。ES UP IE-1、NA PEK ATF6 4。4 7 1 1 2015 7 56 14 Journal of Traditional Chinese Medicine 2015 Vol56
2、No14 Bip/78 GP78 PE K、ATF6、IE-1 G P78 ES GP78 3 UP。2、。2.1“。”“”“。”。“”、。、。、。、5。6。7。“”。“”“”、8 9 TC、TG、LDL-C HDL-C 10。11 TC TC HDL-C、HDL-C/TC。12。2.2“。”“。”、“”。、。、。5 7 1 1 2015 7 56 14 Journal of Traditional Chinese Medicine 2015 Vol56 No14、-。AQP 0 12 13 13。AQP AQP。14 A QP0、AQP0 AQP0、。15 AQP4、AQP4 mNA AQP
3、4 AQP4。16 AQP8 AQP8。17 AQP4 mNA AQP4。3“”、“”。18。、。75%。、。19、。4。“”。mNA mNA mNA。1、2 3 4。、。、。5、。、6 7 1 1 2015 7 56 14 Journal of Traditional Chinese Medicine 2015 Vol56 No14、。ES、。1 Xu C Bailly-Maitre B eed JC.Endoplasmic reticulumstress cell life and death decisions J J Clin Invest 2005 115 10 2656-2664.
4、2 Dobson CM.Principles of protein folding misfolding andaggregation J.Semin Cell Dev Biol 2004 15 1 3-16.3 Schroder M.The unfolded protein response J.MolBiotechnol 2006 34 2 279-290.4 on D Walter P.Signal integration in the endoplasmicreticulum unfolded protein response J.Nat ev Mol CellBiol 2007 8
5、7 519-529.5.M.1997 38-39.6.J.2006 15 15 2029-2030.7.J.1984 4 3 164.8.J 2000 23 2 48-50 9.J 2007 25 2 197-198.10 J 1995 15 1 9-10.11.J.2002 22 1 33-36 12.“”J.2013 54 20 1793-1795.13 Agre P King LS Yasui M et al Aquaporin warerchannels-from atomic Structure to clinical medicine J JPhysiol 2002 542 Pt
6、1 3-16 14.0 AQP0 J.2012 23 7 1641-1644.15.4 J.2004 21 5 369-372.16.8 J.2008 16 4 71-73.17.4 J.2014 29 10 3298-3300.18.“”J.2000 10 2 36-38.19.J 2010 23 2 28-30.Scientific Connotation of“Spleen Governing Transportation and Transformation”and“Spleen Governing Blood”from the Perspective of Endoplasmic e
7、ticulum L Lin 1 WANG Fengyun 1 TANG Xudong 1 WANG Jing 2 HUANG Suiping 2 KANG Nan 3 CHEN Ting 1 WANG Xiaoge 1 ZHU Enlin 3 1 Xiyuan Hospital China Academy of Chinese Medical Sciences Beijing 100091 2 Guangdong Traditional Chinese MedicineHospital 3 Graduate School of Beijing University of Chinese Med
8、icine ABSTACT This paper discusses the scientific connotation of“spleen governing transportation and transformation”and“spleen governing blood”from the perspective of endoplasmic reticulum It introduces the structure and functionof endoplasmic reticulum as well as the effects of endoplasmic reticulu
9、m stress caused by various factors This paperdemonstrates the Chinese medicine theory in three aspects spleen transporting and transforming water and food spleen transporting and transforming fluid and spleen governing blood and analyzes the theory with modern scientificknowledge It concludes that e
10、ndoplasmic reticulum has the closest relationship with the function of the“spleen”inChinese medicine and that spleen-deficiency may essentially be endoplasmic reticulum stress Keywords Spleen governing transportation and transformation Spleen governing blood endoplasmic reticulum endoplasmic reticulum stress spleen-deficiency 2014 11 15 2015 01 16 7 7 1 1 2015 7 56 14 Journal of Traditional Chinese Medicine 2015 Vol56 No14
