1、 1, 2 2 21 430072 2 432000 CS GA 2- GA/CS 1.5 120 6 54.7% 23.3% pH * 1, 2 2 21 430072 2 432000 CS 1 2 3-4 4 5 Albertsson 3 D, L- pH 4 (GA) Scheme 1 O CH 2 OH OH NH 2 O n O CH 2 OH OH NHCOCH 2 O n O(COCH 2 O) m -H O O O OScheme 1 Copolymerization reaction of chitosan with glycolide * 2004Z001 Mw 2160
2、00, 92% 3a Table 1 Table 1 Copolymerization reaction of chitosan with glycolide Entry Copolymer No. GA/CS (w/w) Time (h) Temperature ( ) Yield % Degree of Substituted (%) 1 A 0.5 6 90 52.9 8.4 2 B 1.0 6 90 47.2 10.4 3 C 1.5 6 90 42.4 21.3 4 D 2.0 6 90 33.8 8.4 5 E 1.5 6 60 38.7 9.9 6 F 1.5 6 120 54.
3、7 23.3 7 G 1.5 4 90 41.6 12.7 8 H 1.5 8 90 36.7 8.1 / 140 / / 1.5 6 120 Figure 1 a b 1749.8cm -1 1212.0cm -1 1659.3cm -1 C=O 1641.3 cm -1 2- A, B, C, D, E, F, G, H pH Specific solution content (water uptake) =(W 2 -W 1 )/W 1 W 1 W 2 Figure 2 pH pH pH 2 pH pH=2 pH=6 pH=2 pH=6 pH 4000 3500 3000 2500 2
4、000 1500 1000 500 b a 1421.2 1641.3 1212.0 1659.3 1749.8 T% (cm -1 )Figure 1 FT-IR spectra of chitosan and chitosan copolymer grafted polyglycolic acid (a: chitosan, b: copolymer D) 2345678 1.0 1.5 2.0 2.5 3.0 3.5 4.0 4.5 5.0 5.5 6.0 6.5 7.0 7.5 Specific solution content pHHGFEDCBA Figure 2 Equilibr
5、ium specific solution content (water uptake) of hydrogels as a function of buffer pH pH 1 a) Suh J. K. F., Matthew H. W. T., Biomaterials, 2000, 21(24), 2589-2598; b) Singla A.K., Chawla M., J. Pharm. Pharmacol., 2000, 53 (8), 1047-1067. c) Prabaharan M., Mano J. F., Drug Deliv., 2005, 12 (1), 41-57
6、; Senel S., McClure S. J., Adv. Drug Deliver. Rev., 2004, 56 (10), 1467-1480. 2 Zohuriaan-Mehr M. J., Iran. Polym. J., 2005, 14 (3), 235-265. 3 a) Qu X., Wirsen. A., Albertsson A. C., J. Appl. Polym. Sci., 1999, 74(13), 3193-3202; b) Yang H., Zhou S. B., Deng X. M., Chin. Chem. Lett., 2005, 16(1), 1
7、23-126; c) Liu Y ., Tian F., Hu K. A., Carbohyd. Res., 2004, 339(4), 845-851; Wu Y., Zheng Y. L., Yang W. L., et al, Carbohyd. polym., 2005, 59(2), 165-171. 4 a) Qu X., Wirsen. A., Albertsson A. C., Polymer, 2000, 41(12), 4589-4598; b) Qu X., Wirsen. A., Albertsson A. C., Polymer, 2000, 41(13), 4841
8、-4847; 5 a) Liu, L., Li Y ., Liu H., Fang Y ., Eur. Polym. J., 2004, 40, 2739-2744; b) Kelgo A., Suirinaato D., Kanehik O., JP2003105001, 2003. Preparation and Swelling Properties of Hydrogels Based on Chitosan Grafted Polyglycolic Acid Lian-sheng Wang 1, 2 , Hong-qian Ding 2 , Zhi-quan Guang 21 Sch
9、ool of Resource & Environment Science, Wuhan University, Wuhan, 430072 2 Department of Chemistry, Xiaogan University, Xiaogan, 432000 Keywords: Chitosan Graft Glycolide Hydrogel Copolymers of chitosan grafted polyglycolic acid were synthesized using no catalyst by copolymerizaiton reaction of chitos
10、an with glycolide. Reaction temperatures, times and reactant ratios on yields and substitution degrees of copolymers obtained were investigated. It was found that optimum reaction conditions were as follow, reaction temperatures 120 o C, reaction times 6h, and reactant ratios 1.5, and then, the yiel
11、d and substitution degree of copolymer obtained was 54.7%, 23.3%, respectively. The structures of copolymers were characterized by FT-IR, The swelling behavior of the hydrogel obtained in buffer solution was studied in different pH. The results showed that the hydrogel was pH-sensitive. These preliminary results proved that the copolymerization reaction of chitosan with glycolid was successfully proceeded.
