1、 absorption distribution excretion metabolism Absorption Distribution Metabolism Excretion ADME - transportation elimination transformation disposition , 1. passive transport1.1. - simple diffusionH+HAA-H+BBH-H+HAA-H+BBH- 1 B: HA: pKa pH pH 10pH-pKa= / 10pH-pKa= / HA (B) = A H+ HA = H+ B BH+ p a = p
2、H lg A HA p a = pH lg B BH+ pH p a = lg A HA pH p a = lg B BH+ 10pH p a= A HA 10pH p a= B BH+ pH = p a , HA = A , B = BH+ A-H HA + =+B H BH 2 pKa pH pH 10pH-pKa= / 10pH-pKa= / 2 血液pH 7.4HA = 1A_ = 7943总和HA+A_= 7944 3 pH 2.5HA = 1.0A_= 0.1总和HA+A_=1.1 阿司匹林 pKa 3.5 弱酸性 药 10pH-pKa= 离 子型 / 分 子型 小肠表面pH 7.5B = 1BH+= 3.2总和B + HB_= 4.2血液pH 7.4B = 1BH+= 4总和BH + B_ = 5 吗啡 pKa 8.0 弱 碱 性药 10pH-pKa= 分 子型 / 离子型 H+HAA-H+BBH-H+HAA-H+BBH- 4 pH ion trapping B: HA: - 1.2. filtration ; , aa 1.3. facilitated diffusion carrier transport 2 active transport 3. cytosis- - - - 1234
