1、 l : 2008-03-07 “:SE1 S(I|30670810); 8 S/O “( “I|001110425); 81 S(I|Y205292)Te: (1982-) , o, ,vD V 3,V Y % ?h .3?B%?s0Z刘红蕊 综述,周 韧 审校(vh ED h h 3 “,s310058)K1: 3? B , #B%? : FB% X H 9,Ig VM uy8%lM, Ig , T B% X H4,113?; B %;%;yms |: R733. 4; R730. 23DS M : AcI|: 1001-1692(2008) 05-0483-05 3? B , #B%?
2、b 3?s0MT, P ?B %i,711 u, %M7 % r l%4 Fb u % “ ,r l% ; u%, r l%b 3?y sIgM +IgD+ CD38+B%b ? 38%lM-bt%Vr X 3?B% fS:,VrBcl-2bv30% %VrKi-67bsIgD- CD38+ CD77+B% %,X? 38%lM F,VrBcl-6bsIgD- CD38+ CD77-B% %b %s%, Bcl-6yVr1b%Ig VM uy? 38%lM, ? T FiVrBcl-2,V7 2b 3?Q, T B% s8( BCR)B %$4bB%4V, e b“11 P 3?B%VrJ ,
3、 ?B% FbBV VCD40LaIL-4aIL-10T GF-nulle, CD40LTK1o,7T GF-null V ? 6bT%s %y0: IL-2aIL-4aFasLaCD40LIL-10 % B%sZ_, ; VYVFasL 3?B%, VYVCD40LE b4iB%r u,AG 3?T% MY r l%4 F, ?i 7bBts0T -B%MT: T%Vr ? y0EBCD134B%Vr ? y0s8EBCD134LMT,B%93Ig ; T%Vr ? y0EBCD153B%Vr ? y0 s8EBCD30MT ?B%bGC-T h%yVr CD4+ T%b VrCXCL13,
4、B% r 1oTbCXCL13Vr T CR,i OGCD28 O| 8b2. 1FasFasL 3?B%?TFas,9 CD95, ? y0 s8EBc bFasy 810q23, 3 ea % ? f“d%h?1T 9bFasL,9 CD95L, ?y0EB, FasFas-LMT, V? 3 bFas S Y bFas s8EB, 8a t % =Fb FasL H, s8)d b7FasL, Fas 8, s8$b, s8FasM1 ( Fas-associateddeath domain, FADD)MT, “ 8b8B r, Sprocaspase-8 M, |( death in
5、ducingsignalling complex, DISC)bDISC, , procaspase-8caspase-8bcaspase-8(? /rcaspase, procaspase-3) Qbcaspase-33% = ,% 10b8%lMV 31 =Z T B% HVrFasFas-LbFas s8 , Fas o:Bo y DISC, 3v caspase-8, dbcaspase-3bNH,“ caspase-8caspase-3, VYV 8 cathepsins E 3?B%DNA ,XcathepsinsB V ? Bcl-2EBBid$g Mb 8 VO , 8 0,
6、? y0,Fas 11bB MV 3?B% 8 * Yq,i O scaspase-8 eb BHob=o 3 DISC,AYVL 8Y caspase) QbL 8Y caspase-8g MBcl-2EBBidb o ( V$FADD“IL-1 ( FLIP) 1b2. 2CD40CD40L(CD154) 3?B%?TCD40 ? y0 s8EB, CD40-L ? y0EBbG T%B% fQ,1CD404|b F+sB%41BCRay0CD40/ CD40L ObCD40CD40L Z T:B B%VrCD40,7T%VrCD40L;= 3?B%YVAT -hook cy0AKNA L
7、CCD40CD40L HVrb cy0AKNACD40CD40L 0A/ T“ u eq, VrbAKNA1 BT %aNK% l%Vr 12bCD40CD40L 3?B%9 3i,1YV Z T:B% DNA;= E 3Tbi OCD40/ CD40L V 8,E 8 dbbCD40|YV cy0NF-nullB, V FBcl-2EBBcl-xLmRNAVr 13b2. 3Fas/Fas-LCD40/CD40LWMTB% T FAKNA FasVr/bQ, ?r FB% VFLIP, DISC,c484cJournal of Practical Oncology Vol. 23No. 5
8、2008FasLVr? 3byNB% 3iG : ( 1) CD40O HW; ( 2)Fas/ Fas-L|“db3 r l%(FDC) 3?B%?TFDC 3?W%,v 3?%1%,F 3? “d 14bFDC V4F,G T%8A fQ,E 3?B%bB%T%FDC “d1bFDCVr*s0V CAM-1ICA M-1, FDC 3?B% 3 ( 1oTbV CAM-1ICAM-1/,FDCYV8D6IL-15,| 3i|.r 3?B% 15bFDC %s, u y 9 3B%4 3y0, P sb8 L?C,B%FDCs H,% %bFDCYV F F8 3?B%BCR a , VYV
9、B%FLIPEB%,V7 PB%$4 16bFDCFLIPDISC YVCD40b7 , n5 T FB%YVBCR s8 s 1FDC|, FLIPVr, $, :C F4( VLA-4)% ?M1 F1( LFA-1)bV9 3?B% = =M 18bFDC “d 4 f V ?V 1Tb4 Y 3?B%?s04. 1NF-nullB 3?B%?Tcy0NF-nullBYV Fy c % bNF-nullB FT% LbNF-nullB #InullB nullnull( IKKnullIKKnull)bInullB,N H, NF-nullB db, %y cbNF-nullBd HY
10、:Y 1 F s8TN FnullaIL-1a( LPS)4 IKKnull,TInullBnullaInullBnullInullBnullbY K5NF-nullBs= 8, F p50( NFnullB1)REL-S( p65)REL;dY % nullaTNFEBB%y0( BAFF)CD40IKKnull,p52( NFnullB2) -REL-Bs= 8 db,yVrbNF-nullBB% 3iW AbBCR|YVNF-nullBY P B%ib %MBsB% 1 3i| _? 3L 8 S, 6Bs l , % ,v 00 ?% bV, ?%? s 1 3? 3i| 13b ,E
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