1、g1025g3281g13464g13467g5049g12255g11752g12362g994g1032g5214g5259g3809 g1254414g2379 g1254444g7411 2010g80210g80229g1998g10268 Journal of Clinical Rehabilitative Tissue Engineering Research October 29, 2010 Vol.14, No.44 ISSN 1673-8225 CN 21-1539/R CODEN: ZLKHAH 8311 Department of Urology Surgery, Re
2、nmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China Yu Xiao-huig446, Studying for masters degree, Department of Urology Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China yuxiaohui06126. com Correspondence to: Hu Yun-fei, Doctor, Chief physician, Dep
3、artment of Urology Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China Received:2010-02-08 Accepted:2010-03-08 g3667g1745g1238g3888g3078g2646g4004g4189g2623g2741g3571g2227g275g1813g890g3224g3667g1745g3271 430060 g4133g3787g6271g176g275g2707g2751984 g2733g3219g275g1813g
4、890g3224g1428g4412g3271g3078g275g1745g4514g275g3667g1745g1238g3888g4221g1376g3339g3254g275g4438g3985g1206g3257g3215g4013g4369g99g861g6375g4406g2463g1466g2635g1285g3929g2126g100 yuxiaohi06 g3513g3903g4532g4320g289g1809g4201g1478g275g976g3254g275g4438g3081g4004g3229g275g3667g1745g1238g3888g3078g2646g
5、4004g4189g2623g2741g3571g2227g275g1813g890g3224g3667g1745g3271 430060 hyf6606163. com g1025g3282g2010g12879g2507:R617 g7003g10498g7643g16794g11733:B g7003g12468g13546g2507:1673-8225 (2010)44-08311-04 g3276g1600g3088g2905g2892010-02-08 g3849g1869g3088g2905g2892010-03-08 (20100208004/Mg101H) g11602g10
6、36g6915g6357g13466g14002g11352g10995g10301g4410g10317g5627g2462g11752g12362g17839g4649g446g1325g7207g7210g712g14005g1125g20146 Biological characteristics and research progress of sertoli cellsg3g3Yu Xiao-hui, Hu Yun-feiAbstract BACKGROUND: Sertoli cell has become one of the research focuses in the f
7、ields of cell separation, tissue engineering and organ transplantation, and it has a promising application in clinical transplantation. OBJECTIVE: To summarize the biological characteristics and research progress of sertoli cell at home and abroad. METHODS: Articles addressing sertoli cell were retr
8、ieved from CNKI and Pubmed databases with the key words of “immune privilege, transplantation, function, progress of investigate” in both Chinese and English between January 1998 and October 2009. Articles in the same circle published in the authoritative journals or recently published were selected
9、. There were 215 articles after the initial survey, and 34 articles related sertoli cell were included in the final analysis. RESULTS AND CONCLUSION: Sertoli cell has the function of immune privilege and can secrete various nutrition factors. And it is widely drawn by providing new therapy for organ
10、 transplantation, Parkinson disease and diabetes mellitus. The research about sertoli cell has achieved a lot and presented an extremely captivating prospect in clinical field. It will make a great contribution to the clinical development of mankind. The clinical application of sertoli cell will be
11、wider along with the development of transplantation of tissue engineering and organ transplantation. Yu XH, Hu YF. Biological characteristics and research progress of sertoli cells. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2010;14(44): 8311-8314. http:/ http:/ g6700g16213g3g13984g7235g72
12、6g11602g1036g6915g6357g13466g14002g5062g6116g1038g13466g14002g3533g1871g6228g7427g451g13464g13467g5049g12255g2462g3132g4460g12239g7905g20058g3507g11352g11752g12362g9921g9869g1055g980g712g3324g1032g5214g12239g7905g20058g3507g1025g7389g14403g3921g11352g5224g11004g2081g7235g452 g11458g11352g726g4613g32
13、81g1881g3818g4557g11602g1036g6915g6357g13466g14002g11352g10995g10301g4410g10317g5627g2462g1032g5214g5224g11004g17839g4649g1328g980g13520g17860g452 g7053g8873g726g5224g11004g16757g12651g7438g7828g13046 CNKIg2656 Pubmed g6980g6466g5223g1025 1998g1601/2009g1610 g1863g1122g11602g1036g6915g6357g13466g140
14、02g11352g7003g12468g712g3324g7643g20076g2656g6700g16213g1025g1209“g1825g11135g16917g1825g727g12239g7905g727g2163g14033g727g11752g12362g17839g4649”g6122“immune privilegeg727transplantation; function; progress of investigate”g1038g7828g13046g16801g17839g15904g7828g13046g452g17885g6333g7003g12468g1881g
15、4493g994g11602g1036g6915g6357g13466g14002g7389g1863g13785g712g2528g980g20058g3507g7003g10498g2029g17885g6333g17829g7411g2469g15932g6122g2469g15932g3324g7447g4053g7446g5547g7003g12468g452g2033g7828g5483g2052215g12699g7003g10498g712g7693g6466g13447g1849g7643g1946g17885g6333g1863g1122g11602g1036g6915g6
16、357g13466g14002g1135234g12699g7003g10498g17839g15904g13520g17860g452 g13479g7536g994g13479g16782g726g11602g1036g6915g6357g13466g14002g1867g7389g2010g8864g3822g12193g14841g1871g3252g4388g2656g1825g11135g16917g1825g2163g14033g712g1038g3132g4460g12239g7905g451g5097g18341g7874g11161g2462g12970g4627g1116
17、1g12573g11154g11161g11352g8847g11115g6564g1391g1114g7044g11352g8847g11115g17896g5464g712g4557g11602g1036g6915g6357g13466g14002g11352g11752g12362g5062g13475g2474g5483g1114g980g13007g2027g2499g2928g11352g6116g7536g712g4570g1262g13485g1166g12879g1032g5214g1119g1006g11352g2469g4649g1328g1998g5052g3835g1
18、7141g10498g712g4600g1866g19555g11540g13464g13467g5049g12255g2656g3132g4460g12239g7905g11752g12362g11352g2469g4649g712g11602g1036g6915g6357g13466g14002g3324g1032g5214g8847g11115g1025g11352g5224g11004g5529g4570g7368g2164g5203g8879g452 g1863g19202g16801g726g11602g1036g6915g6357g13466g14002g727g2163g140
19、33g727g11752g12362g17839g4649g727g13520g17860g7003g10498g727g3132g4460g12239g7905 doi:10.3969/j.issn.1673-8225.2010.44.035 g1325g7207g7210g712g14005g1125g20146.g11602g1036g6915g6357g13466g14002g11352g10995g10301g4410g10317g5627g2462g11752g12362g17839g4649J.g1025g3281g13464g13467g5049g12255g11752g123
20、62g994g1032g5214g5259g3809g7122010g71214(44):8311-8314. http:/www.crter.org http:/ 0 g5353g16340 g4560g3577g4358g1115g3717g870(sertoli cell, SC)g1923g2915g2066g1650g3262g4110g4041g1238g2374g4518g4366g3888g1957Enrico Sertolig42211865g2733g3278g3733g1439g3747g1285g1225g4221g4127g3219g2106g3176g2851g43
21、99g1285g4002g4405g1238g3717g870g275g2719g1766g1102g4144g1491g2623g3846g1911g3373g2066g1766g1265g834(androgen binding protein, ABP)g100g4358g1115g3717g870g3609g2106g4496g1439g3219g3476g1634g3678g2360g4358g1098g1764g3639g1351g1285g3601g1836g2114g275g969g1212g2089g2915g4206g3362g275g1838g3609g3409g1285
22、g4079g3969g1764g1439g4162g3476g1634g3406g3859g1285g3717g870g4057g44961g100g994g1260g4221g3775g3219g2106g3176g2851g1166g1310g1212g3839g3750g1911g3373g1285g1718g1105g4399g1439g1864g4482g4399g3287g4532g4104g275g1431g2991g2158g4117g4358g1115g99g4079g3969g99g3549g3264g99g3268g1474g99g1491g2623g99g2631g40
23、38g1890g2631g1289g1407g4405g1631g27192-3g100g2093g2733g2303g4409g1407g3929g2126g4320g4221g4358g1115g3717g870g1285g2434g1173g4075g4104g2089g4282g1466g2635g2199g3251g2089g3835g3440g3404g275g903g3635g2140g4560g3577g4358g1115g3717g870g1285g3219g3678g3888g3467g3839g1923g2434g1173g4075g4104g2089g4282g4141
24、g4027g4504g3309g100 1 g17176g7021g2656g7053g8873 1.1 g6186g2983g3150g3768 g4110g1307g4002g4532g4320g4075g4104g1945g3384g1903g1983g3404CNKI g3316g2156g2255(http:/ g290Pubmed g3316g2156g2255(http:/www. ncbi.nlm. nih.gov/sites/entrez)g3757g1681g3635g3748g100g1983g3404g3240g1975g1459g3606g2891998g1601/2
25、009g1610g100g4399g3635g1983g3404g1197g3609“g2631g4038g1890g2631g290g4013g4369g290g1631g2719g290g3929g2126g2089g4282”g290g4071g3635g1983g3404g1197g3609“immune privilege;transplantation; function; progress of investigate”g100g1643g1983g3404g1278g3635g3748215g2857g100 1.2 g1049g6436g3221g1101 g2700g311
26、0g947g4473 g311g2158g4117g4176g1175g3839g275g2530g1316g2530g2156g2230g2220g1285g3635g4291g100g312g4332g1395g3839g2972g275g3757g1681g1383g1594g1285g3635g3748g100g313g1395g3517g4002g2453g4151g1285g3635g3748g3882g4244g2093g2905g1439g950g1895g3043g1325g7207g7210g712g12573.g11602g1036g6915g6357g13466g140
27、02g11352g10995g10301g4410g10317g5627g2462g11752g12362g17839g4649 P.O. Box 1200, Shenyang 110004 8312 www.CRTER.org g3599g4214g4381g1285g3635g3748g100g2790g1154g947g4473g289g2048g1095g2136g1285g2360g2530g1684g1316g4027g1923g4002g3796g4407g1551g3839g3929g2126g100 1.3 g6158g6617g6015g868 g1146g1983g12
28、84g1278215g2857g3635g3748g275g2915g4399g4071g3635g3635g3748151g2857g275g4399g3635g3635g374864g2857g100g4199g1376g947g3477g1764g4267g3985g2089g3835g1146g3153g275g2790g1154g4144g3929g2126g2690g1285g994g1528g1764g4407g1551g3839g3635g4291g290g1040g4199g3046g3635g275g2801g1390g4144g2700g3110g947g4473g400
29、2g4385g1285g3635g4291g275g4523g1802g3882g424434g2857g1528g1766g947g4473g1285g3635g3748g100 2 g13479g7536 2.1 g4905g1049g2976g4088g1778g3124g2544g1093 g2700g3110g128534g2857g3635g3748g4399g275g4399g3635g3635g37487g2857g275g4071g3635g3635g374827g2857g100g3635g37481-3g3199g1923g4560g3577g4358g1115g3717
30、g870g1285g3833g3423g2066g1650g3467g1316g1568g3309g275g3635g37484-20g3440g3465g4560g3577g4358g1115g3717g870g1285g1631g2719g275g3635g374821-34g3440g3465g4560g3577g4358g1115g3717g870g1285g3929g2126g2089g4282g1923g2434g1173g4075g4104g100 2.2 g4934g3174g2848g6423 g6915g6357g13466g14002g11352g5430g5589g13
31、479g7512g10317g9869g726g4358g1115g3717g870g3833g4465g1594g1383g994g1695g4245g275g1902g998g2085g3500g1902g2663g275g1348g998g3205g3775g2968g2635g275g1031g2635g1764g1685g2968g2635g4117g1779g1407g994g1695g4245g1285g807g3754g275g2915g2717g3759g2963g4482g1618g1929g3219g2106g3717g870g100g969g4110g3717g870g
32、3480g3775g4411g3606g1474g3197g1147g3864g1407g3532g2927g275g3932g3205g1278g1102g3299g1285g3219g2106g3717g870g4365g1975g100g3717g870g1762g1407g3626g4127g1902g1304g275g1762g2663g4117g3864g1407g4420g6946g275g1762g4117g1285g1103g3747g1491g3997g4465g275g1762g2244g1407g275g1762g4393g2184g4203g275g1762g3065
33、g3140g4393g3694g3295g275g3065g3140g2960g275g1762g3077g2652g3745g275g1762g3077g4411g3606g4117g3631g3826g1762g3788g3480g275g4358g1115g3717g870g4117g2157g1238g1285g950g2635g1906g275g2230g4027g3096g2700g3864g1407g1439g4162g4399g1285g3219g2106g3717g870g100g4221g3529g3197g1320g2116g3727g275g3717g870g4393g
34、4399g2230g1998g1779g1407g3756g2380g3480g99g3095g2589g3480g99g4363g1295g99g3450g4176g2226g2380g99g1825g2635g2717g4393g3593g99g1209g2635g2717g4393g3593g1289g100 g11602g1036g6915g6357g13466g14002g11352g2163g14033g726g3g4358g1115g3717g870g1395g3219g2106g3717g870g1285g4532g4104g289g4358g1115g3717g870g422
35、1g2066g1650g3176g3609g3219g2106g3717g870g1285g1491g1828g1102g3299g3476g1634g4358g1967g275g1634g1619g3219g2106g1718g1105g3406g3859g1285g4079g3969g3678g4393g1923g2719g2408g275g3993g2230g1491g2623g3106g3219g1065g4057g4496g2347g99g2347g1669g1183g2347g99g4455g4206g1265g834g2347g99g1336g2059g1265g834g2347
36、g1289g1013g4144g3219g2106g3717g870g1285g1491g1828g1102g3299g275g3800g1336g969g876g4355g2106g4496g1285g1439g3219g4350g1064g4117g3869g2089g3835g100g1618g1929g3219g2106g3717g870g799g1102g3299g1105g1383g4497g2106g3031g3788g1685g1902g1304g998g3775g1685g2968g2790g2425g275g4221g2220g2093g1685g2968g1285g389
37、1g16g4560g2880g4304g3571g1685g2968g1031g1285g3219g2106g3717g870g929g3862g3513g1718g4358g1115g3717g870g2303g1894g3036g4079g3969g100g4358g1115g3717g870g4221g3480g2717g1560g4482g4127g3219g2106g3788g1685g1902g2663g275g2915g3176g6794g1560g4482g3219g2106g3717g870g275g3262g3219g2106g3788g1685g2717g3608g400
38、2g1285g3480g3717g870g100g4358g1115g3717g870g1902g998g3757g1818g1975g4027g2085g2625g2389g2052g3757g2389g1650g1102g3891g16g4560g2880g4304g1285g4407g3985g1102g14914g275g2230g4517g4376g2678g3796g3678g4393g2089g1147g3219g2106g3176g2851g275g3833g1102g969g2991g3611g1115g4117g2374g4127g2106g4496g1439g3219g1
39、285g3601g1836g2114g100g1618g4405g3219g1065g4057g4496g3993g4438g3985g4110g4358g1115g3717g870g1491g2623g4027g4358g1115g2106g4176g3717g870g1285g4249g4370g1764g1491g18285g100g4117g3244g3954g4355g2652g275g1102g3299g4358g1115g3717g870g1285g3316g2408g4144g4505g1285g2106g4496g3833g1102g3316g2408g1103g4350g9
40、136g100g1431g2991g3409g2604g4221g3833g3423g1764g1631g2719g3176g876g1115g3517g996g38397g100g3219g2106g1718g1105g4399g3859g3985g1285g4363g2347g99g3846g1911g3373g99g2081g3307g4173g3373g1764g1618g4405g3611g3219g3373g3262g4144g4358g1115g3717g870g1285g2066g1766g1265g834g3757g2066g1766g969g3291g3362g1278g3
41、219g2106g3717g870g12858g100 g4358g1115g3717g870g1285g1491g2623g1631g2719g289g4358g1115g3717g870g2719g1652g1491g2623g1407g4405g3678g4393g275g2915g4399g1491g2623g1285g1265g834g2347g4438g3985g4117g4455g4206g1265g834g1764g1336g2059g1265g834g275g4455g4206g1265g834g2347g4117g3846g1911g3373g2066g1766g1265g
42、834g99g1665g796g7263g4455g4013g2589g99g4455g3501g1265g834g99g3611g3219g3373g2066g1766g1265g834g99g2459g3382g3450g1265g8341g17642g99g3518g2305g1265g834g1289g290g2915g4399g3467g4051g3839g1491g2623g1285g3846g1911g3373g2066g1766g1265g834g2230g4027g2066g1766g99g4206g3291g1764g2761g3402g3846g1911g3373g275
43、g4027g3611g1115g2915g4221g3031g3717g2106g1685g2717g1285g1594g1731g2408g275g969g2012g2915g1206g3031g3717g2106g1685g2968g4206g3291g1278g1560g4560g100g1336g2059g1265g834g2347g4117g2636g2336g1685g4029g4389g3678g4393(mullerian inhibiting substance, MIS) g4532g3609g4358g1115g3717g870g1623g3467g4051g3839g1
44、285g2631g4038g1983g1033g2214g4176g275g4024g2108g4075g4104g4127g4013g4369g2662g3832g4399g275g969g2719g1491g2623g2717g2851g3373g275g2690g2957g3082g3609g2717g2851g3373g4110g4358g1115g3717g870g1057g3219g1802g3513g1718g2805g1491g2623g1466g3252g1336g2059g4560g3577g1631g27199-10g100g1838g2230g4027g1491g262
45、3g4455g1828g3219g1065g4057g4496g99g4015g1275g3373g3970g3219g1065g4057g4496g99g834g3717g870g2074g33731g99g3219g2106g3219g1065g4057g4496g1923g1891g3839g3373g1289g1407g4405g3219g1065g4057g4496g275g969g4355g3244g2816g3416g2905g1923g1147g3219g1802g3210g2108g3219g1065g4057g4496g1764g3210g2108g4079g3969g33
46、733g4221g4560g3577g4358g1115g3717g870g2717g2230g1115g3875g3839g950g123411-13g100 g4358g1115g3717g870g4144g4560g3577g1975g4393g3717g870g1285g3757g1818g4532g4104g289g3480g2717g1073g171890%g1285g3846g1911g3373g4560g3515g4438g3985g3262g4110g4560g3577g1975g4393g3717g870g1766g1102g1764g1491g2623g1285g100g
47、4358g1115g3717g870g1057g3219g1975g4393g3717g870g1911g1891g1265g834g2719g1212g2089g1975g4393g3717g870g1631g2719g1147g3747g100g4358g1115g3717g870g1057g3219g1285g4029g4389g3373g4221g3513g1718g3727g3021g2711g16g1180g3480g16g3839g3750g4416g2089g3835g1557g1457g2284g1336g2059g4029g4389g2520g2814g1199g1911g
48、3373g1285g1491g2623g275g3517g3240g1395g1975g4393g3717g870g3513g1718cAMPg2927g1212g2089g4532g4104g100g3929g2126g1439g3747g4358g1115g3717g870g2230g1491g2623g1407g4405g3219g1065g4057g4496g4429g3106g1102g3736g3611g3717g870g3219g1065g4057g4496g99g4455g1828g3219g1065g4057g4496g99g950g2851g3219g1065g4057g4
49、496g99g4015g1275g3373g3970g3219g1065g4057g4496g1289g3513g1718g4497g1491g2623g1895g2805g1491g2623g1466g3252g1336g2059g1975g4393g3717g870g1285g1631g271914-15g100g2454g3571g1975g4393g3717g870g1057g3219g1285g4560g3515g2230g4368g2052g4532g4104g4127g3031g3717g3788g1685g4411g3606g1908g3970g3717g870g1285g3846g1911g3373g3283g3480g275g4068g2927g1908g3970g3717g870g2805g1491g2623g4057g4496g1285g1057g3219g275g1395g4358
