1、第十三章 代谢性疾病营养治疗第一节 肥胖症Obesity is defined as an excess body fat content for stature. Ideally, the best assessment of obesity would be a measure of actual body fat. Among adults, the body mass index (BMI, expressed as kg/m2) has been recommended internationally as a measure of obesity. A BMI between 25
2、.0 and 29.9 defines overweight (24.0 to 27.9 for Chinese); a BMI 30 defines obesity (28 for Chinese). Unlike adult, no universal definition of the weight-for-height measures necessary to define obesity in youth exists, but definitions have been proposed. WHO expert committee recommended that for inf
3、ants and children a childs weight for height be compared with mean age- and sex-specific values in the National Center for Health Statistics (NCHS) and WHO reference data. Children with a weight-for-height value 2 standard deviation scores (Z score) above the median are classified as overweight. For
4、 adolescents the committee recommended BMI as the best indicator; however, age and sex must still be considered. Adolescents whose age- and sex-specific BMI is 85th percentile BMI of a reference population are classified as at risk for overweight.Obesity can be viewed as both a disease and a risk fa
5、ctor for chronic disease and other morbidities. Increased fat in the abdominal region predicts physiological risk factors for cardiovascular disease (CVD), independent of body mass. Among adults, both ratio of waist circumference to hip circumference and the waist circumference alone have been used
6、to assess body fat distribution. Waist-to hip ratios 1.0 for men and 0.85 for women have been used to identify people at increased risk for morbidity. For both adults and children, obesity is associated with a higher prevalence of risk factors for cardiovascular disease and type 2 diabetes. People w
7、ith overweight or obesity are more likely than normal-weight people to experience elevated blood pressure; dyslipidemias, such as high levels of total cholesterol, triglycerides, and LDL and low levels of HDL; and insulin resistance. They are also more likely to experience 2 or more these risk facto
8、rs.Ultimately, overweight and obesity are caused by a chronic imbalance between energy intake and energy expenditure. Two behaviors are thought to contribute to energy imbalance; excessive energy intake and inadequate physical activity. Genetics also contribute significantly to obesity. Ultimately,
9、any intervention to facilitate weight loss or prevent weight gain must result in an appropriate relation between energy expenditure and energy intake within the individuals: to facilitate weight loss, expenditure must exceed intake; to prevent weight gain, expenditure must equal energy intake. The g
10、oal of dietary modification is to reduce energy intake. This strategy is an important and effective strategy to facilitate weight loss for both adults and children. Among overweight adults, low-calorie diets (3.35-6.28MJ800-1500 kcal/d) can reduce body weight by an average of 8% over 3-12 months. In
11、creased physical activity may aid weight loss by increasing energy expenditure and by helping maintain lean body mass and thus resting metabolic rate. Increased physical activity contributes modestly to weight loss for both adults and children, but the effect of physical activity alone is generally
12、smaller than that of energy reduction. Physical activity does appear to be important in long-term weight maintenance.一、概述肥胖症（obesity ）是指体内储存过多的脂肪。表现为脂肪细胞体积增大和（或）脂肪细胞数增多。正常成年男子的脂肪组织约占体重的 15%20%，女子占 20%25% 。若成年男子脂肪组织超过 20%25%，女子超过 30%，即为肥胖。常表现为体重超过相应身高体重标准值的 20%以上。按病因和发病机制，肥胖症可分为单纯性肥胖（simple obesity）和
13、继发性肥胖两大类。前者是遗传因素和环境因素共同作用的结果，是一种慢性代谢异常疾病，它常与高血压、高脂血症、冠心病、2 型糖尿病等集结出现或是这些疾病的重要危险因素。随着生活水平的改善和体力劳动的减少，肥胖症有逐年增加的趋势，已成为世界性的健康问题之一。继发性肥胖症是某些疾病（如甲状腺功能减退症、性功能减退症、下丘脑-垂体炎症、肿瘤、库欣综合征等）的临床表现之一。本节主要讨论单纯性肥胖。肥胖症的判断主要是根据理想体重和体质指数，轻度肥胖症者无症状，中重度肥胖症者因体重负荷增大，可出现气急、关节痛、肌肉酸痛、体力活动减少等。通常男性肥胖患者脂肪主要分布在腰部以上，集中在腹部，称为男性型、苹果型肥胖
14、，俗称“将军肚”；女性肥胖患者脂肪主要分布在腰部以下，如下腹部、臀、大腿，称为女性型、梨型肥胖。苹果型比梨型肥胖患者更易发生代谢综合征。公司白领、公务员、财务人员为主，他们每天静坐时间长，普遍缺乏主动锻炼，最易肥胖。患者常因体型而有自卑感、焦虑、内向、抑郁、孤独等心理问题，此外，肥胖患者可伴发高血压、高脂血症、糖尿病、胆石症、胆囊炎等。二、营养代谢特点（一）能量长期能量摄入大于能量消耗量，多余的能量，不管来自哪一类能源物质（脂肪、碳水化合物或蛋白质）均可转变成脂肪储存在体内，过量的体脂储备即可引起肥胖。摄入过多能量可发生在任何年龄，但在幼年开始多食对肥胖的发生具有重要意义。成年起病者多为脂肪细
15、胞体积增大，而幼年起病者多为脂肪细胞数量增多和体积增大，更不易控制。体力活动不足引起的能量消耗下降可能是肥胖的一个原因，也可能是肥胖的后果，因为肥胖病人常受到嘲笑，自卑感强，逐渐形成内向抑郁，不愿活动，因而耗能减少，形成恶性循环。因此，应控制能量摄入和增加能量消耗，才能纠正能量代谢的失衡。（二）脂肪和碳水化合物膳食脂肪的能量密度高，过多摄入易使能量超标，且易发生酮症。饱和脂肪酸易转化为体脂，引起肥胖。有学者认为，机体有一控制系统调节体脂含量固定在某一水平，称为调定点（set point）。肥胖症的调定点较高，因而难以减重，或减重后难以维持。单、双糖消化吸收快，易使机体遭受多糖的冲击性负荷，而反
16、馈性胰岛素过度分泌，后者促进葡萄糖进入细胞合成体脂。（三）蛋白质肥胖病人由于限制膳食能量摄入量，会引起机体组织蛋白分解，易发生蛋白质营养不良，故应提高低能量膳食中蛋白质，尤其是优质蛋白质的比例。但蛋白质摄入过量，含氮代谢产物增加，会加重肝肾负担。三、营养治疗原则（一）营养治疗的目的肥胖是一种慢性病，因长期能量摄入超过能量消耗所引起。因此，应持之以恒，长期坚持控制能量摄入，和增加体能消耗，促进体脂分解，切不可急于求成。预防肥胖比治疗容易且更有意义。营养治疗的目的是通过长期摄入低能量的平衡膳食，结合增加运动，借以消耗体脂，从而减轻体重，同时又能维持身心健康。（二）营养治疗原则1. 限制总能量摄入量
17、 能量供给量应低于能量消耗量。成年轻度肥胖症，以比平日减少能量摄入125250kcal（0.5231.046MJ）/d 来配制一日三餐的膳食；中重度肥胖症，减少 5001000kal（2.0924.184MJ ）/d，但每人能量摄入量不应少于 1000 kcal（4.184MJ ）/d ，这是较长时间能坚持的最低水平。减少能量摄入量应循序渐进，切忌骤然降至最低水平以下。体重也不宜骤减，一般以每月减重 0.51.0kg 为宜。2. 限制脂肪摄入 脂肪应占总能量的 20%25% ，不宜超过 30%；膳食胆固醇供给量以少于 300mg/d 为宜。饮食中以控制肉、蛋、全脂乳等动物性脂肪为主，烹调用油控
18、制在 1020g/d，宜用植物油，以便提供脂溶性维生素和必需脂肪酸。食物宜以蒸、煮、炖、拌、卤等少油烹调方法制备为主，以减少用油量。3. 适当减少碳水化合物摄入 膳食碳水化合物占总能量 45%60%为宜，过低易产生酮症，过高会影响蛋白质的摄入量。应以复合碳水化合物为主，如谷类，尽量少用或不用富含精制糖的食品，如甜的糕点。主食一般控制在150250g/d。4. 蛋白质供给要满足需要 低能量膳食主要是控制脂肪和碳水化合物摄入量，而蛋白质供给应充足，否则不利于健康。但过多蛋白质也不利于减重。一般蛋白质占总能量的 20%30%为宜，每公斤理想体重 1g/d 以上，其中至少有 50%为优质蛋白质，来自肉
19、、蛋、奶和豆制品。5. 充足的维生素、无机盐和膳食纤维 膳食除通过调整三大宏量营养素来限制能量摄入量外，其它营养素，包括各种无机盐和维生素应供给充足，且比例要均衡。新鲜蔬菜和水果是无机盐和维生素的重要来源，且富含膳食纤维和水分，属低能量食物，有充饥作用，故应多选用。必要时可适量补充维生素和无机盐制剂，以防缺乏。因肥胖常伴高血压等，为了减少水在体内潴留，应限制食盐摄入量，每人不宜超过 6g/d。6. 养成良好的饮食习惯和积极运动 宜一日三餐、定时定量，晚餐不应吃得过多过饱；少吃零食、甜食和含糖饮料；吃饭应细嚼慢咽，可延长用餐时间，这样即使食量少也可达到饱腹感；可先吃些低能量的蔬菜类食物，借以充饥
20、，然后再吃主食；酒不利于脂肪和糖代谢，应尽量少饮。积极并坚持运动，既可增加能量消耗，减少体脂，又可保持肌肉组织强健。因此，调节膳食减少能量摄入量和配合运动增加能量消耗，双管齐下是减肥的最佳方法。四、食物选择（一）宜用食物谷类、各种瘦肉、鱼、豆、奶、蛋类均可选择，但应限量。蔬菜和水果可多选用。（二）忌（少）用的食物富含饱和脂肪酸的各类食物，如肥肉、猪牛羊油、椰子油、可可油等，以及各类油炸、煎的食品；富含精制糖的各种糕点、饮料，零食和酒类。（三）食谱举例（表 13-1-1）表 13-1-1 成年人肥胖症参考食谱早餐 豆浆（300ml ），面包（面粉 50g）午餐 米饭（大米 75g），蒸咸蛋（ 40g）猪肉（50g）饼，凉拌西红柿（200g）、淡菜（10g）冬瓜（200g）鲫鱼（50g）汤晚餐 油菜（100g）虾米（10g）汤面（75g），牛肉（50g）炒芹菜（150g），苹果 150g能量 4.920MJ（1176kcal） 蛋白质 67.4g（22% ）脂肪联单 32g（24% ） 碳水化合物 162g（55%）注：全日烹调用油 12g
