1、 31 10 2013 10 J Clin Pediatr Vol.31 No.10 Oct.2013 985 doi:10.3969 j.issn.1000-3606.2013.10.025 ( 530021) nicotinamide phosphoribosyl transferase NAMPT nicotinamide adenine dinucleotide NAD + NAMPT NAD + NAMPT NAMPT APO866/FK866 B R73 A 1000-3606 (2013) 10-0985-05 Nicotinamide phosphoribosyltransfe
2、rase in in ammation and cancer Nicotinamide phosphoribosyltransferase in in ammation and cancer Reviewer: WANG Mengjie, LI Xinye, Reviser: Reviewer: WANG Mengjie, LI Xinye, Reviser: LAN Dan (Department of Pediatrics, First Af liated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, Ch
3、ina) LAN Dan (Department of Pediatrics, First Af liated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China) Abstract: Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the salvage pathway for the biosynthesis of nicotinamide adenine dinucleotide (NAD+)
4、 from nicotinamide. NAMPT is also a cytokine that inhibits the apoptosis of neutrophils under various in ammatory stimuli, regulates various diseases and closely associates with the progression and prognosis of cancers. However, it is still not clear whether the cytokine-like function of NAMPT is in
5、terrelated with the biosynthesis enzyme activity of NAD+. This article aims to provide novel insights for inflammation and cancers treatment by reviewing the function of NAMPT in inflammation, carcinogenesis, cancer progression and its inhibitors, APO866/FK866. (J Clin Pediatr,2013,31(10):985-989) K
6、ey words: pre-B-cell colony-enhancing factor; nicotinamide phosphoribosyltransferase; visfatin; in ammation; cancer B pre-B-cell colony-enhancing factor PBEF nicotinamide phosphoribosyl transferase NAMPT visfatin PBEF 1994 Samal 1 B -7 IL-7 SCF B 2001 Martin 2 nicotinamide adenine dinucleotide NAD +
7、 nadV NAD + nadV PBEF PBEF NAD + 2005 Fukuhara 3 PBEF visfatin Revollo 4 visfatin PBEF NAMPT HUGO NAMPT NAMPT NAMPT iNAMPT eNAMPT iNAMPT NAD + eNAMPT NAD + 4-6 NAMPT NAMPT 1 iNAMPT NAD + NAD + L- 3 NAD + Imai 7 NAD + NAD +World NAMPT NAD + NAMPT NAD + NAMPT NAD + NAMPT NAD + 5 -1 NMN 4 NMN NAD + NAM
8、PT (No. 81060045) 31 10 2013 10 J Clin Pediatr Vol.31 No.10 Oct.2013 986 NAD + NAD + NAMPT NAD + NAMPT ATP NAD + 8-10 NAD + NAD + 11 12 NAD + NAD + NAMPT NAD + NAD + NAD + NAMPT NAD + NAD + sirtuins NAD + 3 13 NAMPT NAD + 10 14 ADP 15 Sirt1 sirtuin type 1 NAD + Sirt1 16 NAMPT NAD + -Sirt1 NAD + sirt
9、uin-1dependent pathway G-CSF G-CSF 2009 NAMPT G-CSF NAD + Sirt1 sirtuin type 1 CCAAT/ - CCAAT/ - G-CSF NAMPT 17 silent information regulater 2 Sirt 2 18 NAMPT Sirt2 B/ KAT/ -3 / - NAMPT Sirt2 13 2 eNAMPT eNAMPT NAMPT IL-6 IL-8 19 20 CD14 + NAMPT IL-1 TNF- IL-6 CD54 CD40 CD80 295 NAMPT IL-6 C- CRP NA
10、MPT 21 eNAMPT eNAMPT eNAMPT 19 20 IL-1 TNF- eNAMPT 22 NAMPT mRNA 23 NAMPT 24 25 26 27 eNAMPT eNAMPT NAMPT 22 eNAMPT NMN APO866/ FK866 28 eNAMPT eNAMPT NAD + 3 NAMPT NAMPT visfatin visfatin 3 visfatin 29 visfatin 30 NAMPT NAMPT visfatin visfatin visfatin 23 TNF- NAMPT THP-1 NAMPT 31 NAMPT 4 NAMPT 4.1
11、 NAMPT NAMPT NAMPT 6 32 PC3 NAMPT 1/2 ERK1/2 MMP-2/9 p38 33 NAMPT 31 10 2013 10 J Clin Pediatr Vol.31 No.10 Oct.2013 987 NAMPT 34 T- NAMPT FK866/ APO866 24 h NAD + NAD + 35 FK866/APO866 FK866/APO866 35 FK866/APO866 NAMPT Sirt2 NAMPT Sirt2 B/AKT/ -3 /- NAMPT Sirt2 13 NAMPT 4.2 NAMPT 36 NAMPT NAD + NAD + NAD + NADH NADH ATP NADH NAD + /NADH 37 NADH/NAD + PT 38 PT NADH/NAD + NAD + Caspase DNA DNA fragmentation factor DFF40 DFF40 DNA 39 DFF40 DNA 40 NAD + Surtuins 41 NAMPT NAMPT 42 ERK1/2 NAMPT ERK1/2 ERK NAMPT 43 NAMPT -2 FGF-2 NAMPT NAMPT ERK1/2- FGF-2 FGF-2 44 NAMPT-FGF-2 NAMPT
