1、 声明：本文摘自 Journal of Cancer Therapy，是一本由科研出版社（ Scientific Research Publishing）出版的关于癌症治疗领域最新进展的国际期刊。该期刊旨在为全世界的医生和学者提供一个分享、讨论各种癌症相关问题的平台。为方便广大读者阅读，我们对论文摘要进行了中文翻译，译文仅供参考，如有不足之处，敬请指正。-本文摘自舞茸 D-fraction 官方网站，转载请注明【参考译文】Improved Anticancer Effects on Various Cancers with Combinations of Chemotherapeutic Dr
2、ugs or Vitamin C and D-Fraction舞茸 D-Fraction 与化疗药物或维生素 C 合用能改善对多种癌症的抗癌效果摘 要尽管化疗是很多癌症患者的多种选择之一，但是在很多案例中因为其明显的副作用使满意度降低。为帮助改善化疗的效果，我们检测了一种具有生物活性的菇类提取物 D-fraction (DF)在人体内是否能增强各种药物的抗癌效果。我们试验各种化疗药物和 DF 联合使用对七种癌细胞系即乳腺癌，肺癌，胃癌，结肠癌，前列腺癌，膀胱癌以及肾癌的效果。与单独使用化疗药物相比，它们与 DF 联合使用时确实能改善抗癌效果，能明显降低癌细胞的生存率（p70%), ACHN,
3、T24, PC-3, Caco-2, and AGS cells, show statistically the significant improvement in the cell viability reduction with combinations of specific drugs and DF (compared to individual drug alone). It thus appears that DF could help improve the efficacy of many drugs significantly. However, as such an im
4、provement somewhat varies with cancer types, it will be crucial to explore how different drug/DF combinations would actually work or to better understand their underlying mechanisms. Such study is currently underway in our laboratory.Additionally, as a unique approach, we examined if combination of
5、DF (300 g/ml) and VC (200 M) might also have some anticancer effects on those cancer cells. Remarkably, such DF/VC combination was capable of inducing a drastic 90% cell viability reduction in six cancer cell lines except for a 70% viability reduction in one cancer cell line (Table 1). To gain an in
6、sight into how such a profound viability reduction is induced by DF/VC combination, possible induction of apoptosis was examined. We found that DF/VC combination led to the down-regulation of anti-apoptotic bcl-2 concomitant with the up-regulation of pro-apoptotic Bax (Figure 2), indicating inductio
7、n of apoptosis 16. Therefore, the cell viability reduction induced by DF/VC combination is presumably attributed to apoptotic cell death.Nevertheless, it is rather critical to elucidate the cytotoxic mechanism of DF/VC combination, although our separate study indicates a possible involvement/role of
8、 oxidative stress. More studies are required for further confirmation.Taken together, DF/VC combination appears to be superior to any drugs alone or any combinations of drugs and DF tested, and may ultimately induce apoptosis in these cancer cells.5. ConclusionThe present study suggests that D-fract
9、ion may have a great potential as an adjuvant agent that can be combined with certain chemotherapeutic drugs or with vitamin C for the safer and more effective therapeutic modalities for various human malignancies. Further studies are thus warranted.6. AcknowledgementsWe thank Mr. Mike Shirota (Mush
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22、2008.307*Corresponding author.Received April 9th, 2013; revised May 10th, 2013; accepted May 18th, 2013Copyright 2013 Sensuke Konno et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
