1、,Tuberculous Abdomen,Circumferential ulceration is characteristic of intestinal tuberculosis.,Epidemiology of GI TB,Extrapulmonary TB represented 28.2% of all reported TB cases. Gastrointestinal TB was the 2nd most common type of TB.,Extrapulmonary TB: difficult to diagnose?,Several forms of extrapu
2、lmonary TB lack any of the localizing symptoms or signs. Cutaneous anergy to PPD was noted in 35-50% of patients. No clinical or radiological evidence of pulmonary TB could be found in up to one 3rd of these patients.,Introduction,TB can involve any part of GIT from mouth to anus, peritoneum & pancr
3、eatobiliary system. Varied presentations.,PREVALENCE,Isolated abdominal tuberculosis: Unselected autopsy series- 0.02 - 5.1%Higher prevalence in females Despite increased Pul TB in malesSecondary to Pul. TB,HIV & TB,Before era of HIV infection 80% TB confined to lung Extrapulmonary TB increases with
4、 HIV 40 60% TB in HIV+ pt - extrapulmonary,Incidence severity of abdominal TB will increase with the HIV epidemic,Pathogenesis,Mechanisms by which M. tuberculosis reach the GIT: Hematogenous spread from primary lung focus Ingestion of bacilli in sputum from active pulmonary focus. Direct spread from
5、 adjacent organs. Via lymph channels from infected LN,Robert Koch, a German Scientist who found out the causative organism and revealed his invention in1882,Gram negative bacillus Mycobacterium tuberculosis,Tuberculous abdomen is a condition in which there is tuberculous infection of the peritoneum
6、or other organs in the abdomen,Tuberculous peritonitis,Acute tuberculous peritonitis Chronic tuberculous peritonitis,Acute tuberculous peritonitisAcute abdomen with severe pain Acute inflammation of the peritoneum Straw coloured fluid Tubercles in the greater omentum and peritoneum Tubercles may cas
7、seate Anti tuberculous treatment,Chronic tuberculous peritonitisThe condition presents with abdominal pain Fever Loss of weight Ascites Night sweats Abdominal mass,Origin of infectionTuberculous mesenteric lymph nodes Tuberculosis of the ileocaecal region Tuberculous pyosalpinx Blood borne infection
8、 from pulmonary tuberculosis, usually the miliary but occasionally the cavitating form,Varieties of tuberculous peritonitis Ascitic form peritoneal fluid distension of abdomen. Patient comes with the complaint of swelling of the abdomen. increased abdominal pressure umbilical hernia, inguinal hernia
9、 Purulent formRare usually secondary to tuberculous salpingitis pockets of adherent intestines and omentum containing tuberculous pus. cold abscesses Encysted formInflammation and ascites are confined to one part of the abdominal cavity Fibrous formWide spread adhesions adhesive obstruction,Peritone
10、al involvement occurs from : Spread from LN Intestinal lesions or Tubercular salpingitis Abdominal LN and peritoneal TB may occur without GIT involvement in 1/3 cases.,GI TB,GI tuberculosis is usually secondary to pulmonary tuberculosis, radiologic evaluation often shows no evidence of lung disease,
11、GI Tuberculosis,Ileocecum and Colon The ileocecal region is the most common area of involvement in the gastrointestinal tract due to the abundance of lymphoid tissue. The natural course of gastrointestinal tuberculosis may be ulcerative hypertrophic or ulcerohypertrophic.,Most common site - ileocaec
12、al region Increased physiological stasis Increased rate of fluid and electrolyte absorption Minimal digestive activity Abundance of lymphoid tissue at this site.,Distribution of tuberculous lesions,Ileum caecum ascending colon jejunum appendix sigmoid rectum duodenum stomach oesophagusMore than one
13、site may be involved,Clinical Features,Mainly disease of young adults 2/3 of pt. are 21-40 yr old Sex incidence equal.slight female predominance Clinical presentation Acute / Chronic / Acute on Chronic.,Constitutional symptoms Fever (40%-70%) Weight loss (40%-90%) Anorexia Malaise Pain (80%-95%) Col
14、icky Continous Diarrhoea (11%-20%) Constipation Alternating constipation and diarrhoea,Tuberculosis of esophagus,Rare 0.2% of total cases By extension from adjacent LN Low grade fever / Dysphagia / Odynophagia / Midesophageal ulcer Mimics esophageal Ca,Gastroduodenal TB,Stomach and duodenum each 1%
15、of total cases Mimics PUD - shorter history, non response to t/t Mimics gastric Ca. Duodenal obstruction - extrinsic compression by tuberculous LN Hematemesis / Perforation / Fistulae / Obstructive jaundice Cx-Ray usually normal Endoscopic picture - non specific,Ileocaecal tuberculosis,Colicky abdom
16、inal pain Ball of wind rolling in abdomen Right iliac fossa lump - ileocaecal region, mesenteric fat and LN,Segmental / Isolated colonic tuberculosis,Involvement of the colon without involvement of the ileocaecal region9.2% of all cases Multifocal involvement in 1/3 (28% to 44%) Median symptom durat
17、ion 1 year,Colonic tuberculosis,Pain - predominant symptom ( 78%-90% ) Hematochezia in 1/3 - usually minor Overall, TB accounts for 4% of LGI bleeding Other features- fever / anorexia / weight loss / change in bowel habits,Rectal and Anal Tuberculosis,Hematochezia - most common symp. Due to mucosal
18、trauma by stool Constitutional symptoms Constipation Rectal stricture Anal fistula usually multiple,Complications,GIT bleeding Obstruction Perforation Malabsorption,Obstruction,Most common complication Pathogenesis Hyperplastic caecal TB Strictures of the small intestine- commonly multiple Adhesions
19、 Adjacent LN involvement traction, narrowing and fixation of bowel loops. Series of 348 cases of intestinal obstruction - TB in 54 (15.5%) (Bhansali and Sethna).,Perforation,Usually single and proximal to a stricture Clue - TB Chest x-ray Pneumoperitoneum ?,Malabsorption,Common Decreased absorption
20、Increased Consumption,Emaciation due to TB,Overall prevalence of malabsorption:,75% pt with intestinal obstruction 40% of those without (Tandon et al),Investigations Blood routine PPD test Ascitic fluid examination X-ray s Endoscope Laparoscopy,Blood tests,Non specific findings- Raised ESR Positive
21、PPD test Anemia ADA Hypoalbuminaemia Co HIV infection ?,PPD Test,PPD test positive,Measuring the induration PPD test,Ascitic fluid examination,Straw coloured Protein 3g/dL Lymphocytes 70% SAAG 1.1 g/dL + culture in 20% cases,Adenosine Deaminase (ADA),Aminohydrolase that converts adenosine inosine AD
22、A increased due to stimulation of T-cells by mycobacterial Ag Serum ADA 54 U/L Ascitic fluid ADA 36 U/L Ascitic fluid to serum ADA ratio 0.985 ( Bhargava et al) Coinfection with HIV normal or low ADA,X-rays,Gastrointestinal Tuberculosis,Barium studies demonstrate spasm and hypermotility with edema o
23、f the ileocecal valve in the early stages Later thickening of the ileocecal valve. A widely gaping ileocecal valve with narrowing of the terminal ileum (Fleischner sign) A narrowed terminal ileum with rapid emptying of the diseased segment through a gaping ileocecal valve into a shortened, rigid, ob
24、literated cecum (Stierlin sign) Focal or diffuse aphthous ulcers : tend to be linear or stellate, following the orientation of lymphoid follicles (ie, longitudinal in the terminal ileum and transverse in the colon),Gastrointestinal Tuberculosis,In advanced cases, symmetric annular stenosis and obstr
25、uction associated with shortening, retraction, and pouch formation may be seen. The cecum becomes conical, shrunken, and retracted out of the iliac fossa due to fibrosis, ileoceacal valve becomes fixed, irregular, gaping, and incompetent .,52,Tuberculous peritonitis USGM Intestines floating in perit
26、oneal fluid - ascites,Colonoscopy,Colonoscopy - mucosal nodules & ulcers Nodules Variable sizes (2 to 6mm) Most common in caecum especially near IC valve. Tubercular ulcers Large (10 to 20mm) or small (3 to 5mm) Located between the nodules Single or multiple Transversely oriented / circumferential c
27、ontrast to Crohns Healing of these girdle ulcers strictures Deformed and edematous ileocaecal valve,Colonoscopic Diagnosis,8 10 Bx from ulcer edge Low yield on histopath as mainly submucosal disease Granulomas in 8%-48% Culture positivity in 40% Combination of histology & culture diagnosis in 60%,La
28、paroscopic Findings,Thickened peritoneum with tubercles- Multiple, yellowish white, uniform ( 4-5mm) tubercles Peritoneum is thickened & hyperemic Omentum, liver, spleen also studded with tubercles. Thickened peritoneum without tubercles Fibro adhesive peritonitis Markedly thickened peritoneum and m
29、ultiple thick adhesions (Bhargava et al),Differential diagnosis,CD Cancer Lymphoma Chronic colitis,Management,isoniazid rifampicin pyrazinamide ethambutol Surgical intervention when needed,at least 6 months including 2 months of Rif, INH, Pzide and Etham However in practice t/t often given for 12 to
30、 18 months obstructing lesions may relieve with Med aloneHowever most will need surgery,Tx duration,Newly diagnosed: 2HRZE/4HR、2SHRZ/4HR Relapsed: 2HRZSE/46HRE,CD or TB?,The ultimate course of these two disorders is different. Intestinal TB is entirely curable, provided that the diagnosis is made ea
31、rly enough and appropriate treatment is instituted. In contrast, CD is a progressive relapsing illness. Unfortunately, it is difficult to differentiate intestinal TB from CD because of similar clinical, pathological, radiological, and endoscopic findings.,Diagnosis: intestinal TB or CD,They can pres
32、ent exactly with same clinical pictures (same age group, symptoms and signs) Same radiological findings and same endoscopic findings Mostly with same pathological findings So how can we make the diagnosis?,? Other features,History of previous TB CXR findings of TB The tuberculin skin test is less he
33、lpful, because a positive test does not necessarily mean active disease. Perianal fistulae and extraintesitnal manifestations of CD If all negative: any other clues?,Multiple attempts!,Endoscopic findings? Laproscopic findings? Histological findings? PCR? Empirical TB?,Endoscopic diagnosis?,CD (4 pa
34、rameters) Anorectal lesions, longitudinal ulcers, aphthous ulcers, and cobblestone appearance Intestinal TB (4 parameters) involvement of fewer than four segments, a patulous ileocecal valve, transverse ulcers, and scars or pseudopolyps,Endoscopy. 2006 Jun;38(6):592-7.,Endoscopic diagnosis?,Lee et a
35、l hypothesized that a diagnosis of Crohns disease could be made when the number of parameters characteristic of Crohns disease was higher than the number of parameters characteristic of intestinal tuberculosis, and vice versa.,Endoscopy. 2006 Jun;38(6):592-7.,Endoscopic findings: TB,In tuberculosis
36、patients, transverse ulcers with surrounding hypertrophic mucosa and multiple erosions were usual colonoscopic findings.,Am J Gastroenterol 1998;93: 606609. Gastrointest Endosc 2004;59:362-8.,Typical transverse ulcer,Gastrointest Endosc 2004;59:362-8.,Radiology,thickened bowel wall with distortion o
37、f the mucosal folds and ulcerations. CT may show preferential thickening of the ileocecal valve and medial wall of the cecum and massive lymphadenopathy with central necrosis. Calcified mesenteric lymph nodes and an abnormal chest film are other findings that aid in the diagnosis of intestinal tuber
38、culosis.,At surgery: TB,Reduced largely since introduction of colonoscopy Indications: Mass lesions associated with the hypertrophic form, because they can lead to luminal compromise with complete obstruction. Surgery also may be necessary when free perforation, confined perforation with abscess for
39、mation, or massive hemorrhage occur. Findings: The bowel wall appears thickened with an inflammatory mass surrounding the ileocecal region. The serosal surface is covered with multiple tubercles. The mesenteric lymph nodes frequently are enlarged and thickened.,Histologically,Intestinal TB: granulom
40、as are Large, multiple, confluent with caseation Ulcers lined by epitheliod histiocytes CD Fissuring ulcer, lymphoid aggregates, transmural inflammation, and Infrequent, small, noncaseating granulomas.,Am J Gastroenterol 2002;97:1446 1451. Pulimood et al. Gut 1999,Empirical anti-TB,If intestinal TB
41、still possibility, give 4-6 weeks of anti-TB 30% of CD patietns at China receives anti-TB before final diagnosis,Presumptive diagnosis,can be established in A patient with active pulmonary tuberculosis and radiologic and clinical findings that suggest intestinal involvement. Response to anti-TB,Thank you!,
