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本文(低密度脂蛋白作为药物靶向载体的研究进展.pdf)为本站会员(weiwoduzun)主动上传,道客多多仅提供信息存储空间,仅对用户上传内容的表现方式做保护处理,对上载内容本身不做任何修改或编辑。 若此文所含内容侵犯了您的版权或隐私,请立即通知道客多多(发送邮件至docduoduo@163.com或直接QQ联系客服),我们立即给予删除!

低密度脂蛋白作为药物靶向载体的研究进展.pdf

1、24 ,/, !,.W 8 Fs4 |# ?%T J .S=_D, 2007, 28(12):1088-1090,1093.25;, , +k ,.rW 4 |A sF%BGC2823T J . H SDS0, 2006, 17(9):1695-1696.26;, , +k ,.rW 4!#8 = F ?T J . ?,2007,27(4):333-334.27f,;, +k ,.rW c0 bHepG-2%9T J .00 “50 ,2007,18(4):257-259.28 , , . “5 F ?0 FlM J .S0,1992,17(7):431-432.29 ,|$ %TV b“。Y

2、VLDL s8V VrHela% FMCF-7% LTV , 0M1, LDL-0IC50 A,r2.4 8.6, LDL-0YVLDL s8o ?r40%T。Masquelier7| 4WB4291F LDL,z % WB4291 z 。8% LV ,WB4291-LDL hK562%HL60% A%T,S xCHO% LDL s8 JlM%?。Corbin 14|d+s H/4Gd-DTPA-SA 3LDLs0s0,!1LDL s8_MRI/4。8V , Gd-DTPA-SA-LDL; =? LDLM V , =LDL s8% = ?。HepG2 M ? L, Gd-DTPA-SA-LDL

3、24 hA UF A ?/,7#| Ah 。Crich15 Gd-AAZTAC17 S/4 Gd-DOTA、Gd-DTPA60%,A U 2 , O z , LDL :1r 3001, O YLDL s8 T。 ?B16l 8 =L, 8 hGd-AAZTAC17-LDLF ?| ,. T08Z J .S 30,2003,24(2):-.6 Kader A,PaterA.Loadinganticancerdrug intoHDLaswellasLDL haslittle affectonpropertiesof complexes and enhancescytotoxicity to hu-

4、mancarcinoma cells J .J Controlled Release,2002,80(1-3):29-44.7 Masquelier M, Lundberg B, Peterson C, et al.Cytotoxic effect of alipophlic alkylating agent after incorporationinto low density lipoproteinor emulsions:studies inhuman leukemic cells J .Leuk Res,2006,30(2):136-144.8 Reddy G R, Bhojani M

5、 S, McConville P, et al.Vascular targetednanoparticles for imaging andtreatmentof braintumors J .ClinCancerRes,2006,12(22):6677-6686.9 Bonneau S,Vever-Bizet C,Mojzisova H,et al.Tetrapyrrole-photosensi-tizersvectorizationandplasma LDL:A physico-chemical approach J .Int JPharm,2007,344(1-2):78-87.10 L

6、i H,Marotta D E,Kim S,et al.Highpayloaddelivery ofoptical imag-ing andphotodynamictherapy agentsto tumorsusingphthalocyanine-re-constituted low-density lipoprotein nanoparticles J .J Biomed Opt,2005,10(4):41203.11 Frias J C,Lipinski M J,Lipinski S E, et al.Modified lipoproteins ascontrastagents for

7、imaging of atherosclerosis J .Contrast Media MolImaging,2007,2(1):16-23.12 Sobal G, Menzel E J, Sinzinger H.Comparative binding of 125I-and99m Tc-labelednative and glycated low-density lipoprotein to human mi-crovascular endothelial cells-potential for atherosclerosis imaging J .JReceptSignal Transd

8、uct Res,2006,26(5-6):693-707.13 Urizzi P,SouchardJP, RatovoG,et al.Useof 111In-L-LDL radiotracersto detect human pancreatic and mice melanoma tumors J .ApplOrganometalChem,2003,17(4):212-217.14 Corbin I R,LiH,ChenJ,et al.Low-density lipoproteinnanoparticlesasmagnetic resonance imaging contrast agent

9、s J .Neoplasia,2006,8(6):488-498.15 CrichSG,LanzardoS,Alberti D,et al.Magnetic resonance imagingde-tection of tumor cells by targeting low-density lipoprotein receptor withGd-loaded low-density lipoprotein particles J .Neoplasia, 2007, 9(12):1046-1056.16 Mitsumori L M, Ricks J L, Rosenfeld M E, et a

10、l.Development of alipoproteinbasedmolecular imagingMRcontrast agent for the noninva-sive detectionof early atheroscleroticdisease J .IntJCardiovascImag-ing,2004,20(6):561-567. 17 LiH,Gray B D,CorbinI,et al.MRandfluorescentimaging of low-den-sity lipoproteinreceptors J .Acad Radiol,2004,11(11):1251-1

11、259. 18 Frangioni JV.In vivo near-infraredfluorescenceimaging J .Curr OpinChem Biol,2003,7(5):626-634.19 Stefflova K,ChenJ,Zheng G.Using molecular beaconsfor cancer imag-ing andtreatmentJ .Front Biosci,2007,12(12):4709-4721.20 + ,Z ,.S:/ 3D0 5 J .0 3/ ,2006,13(4):306-309.21 WuSP,LeeI,GhoroghchianPP,

12、etal.Near-infraredopticalimaging ofB16melanoma cells via low-density lipoprotein-mediated uptake anddelivery ofhigh emission dipole strength tris(porphinato)zinc()fluorophores J .Bioconjug Chem,2005,16(3):542-550.22 Zheng G, LiH, Yang K,et al.Tricarbocyanine cholesteryl laurates la-beledLDL:new near

13、 infrared fluorescent probes(NIRFs)for monitoringtumors and gene therapy of familial hypercholesterolemia J .BioorgMedChem Lett,2002,12(11):1485-1488.23 Zheng G,Chen J,LiH,et al.Rerouting lipoprotein nanoparticles to se-lectedalternate receptors for the targeted delivery of cancer diagnosticandthera

14、peutic agents J .Proc Natl AcadSci USA,2005,102(49):17757-17762.24 Leamon C P, Reddy JA.Folate-targeted chemotherapy J .Adv DrugDeliv Rev,2004,56(8):1127-1141.25 Maranho RC,TavaresE R,Padoveze A F,et al.Paclitaxel associatedwith cholesterol-rich nanoemulsions promotes atherosclerosis regressioninthe rabbit J .Atherosclerosis,2008,197(2):959-966.26 NikanjamM,GibbsA R,Hunt C A,et al.Synthetic nano-LDLwithpa-clitaxeloleate as a targeted drug delivery vehicle for glioblastoma multi-forme J .JControlled Release,2007,124(3):163-171.67S 30Chinese Journal of Biochemical Pharmaceutics 2009 M30 1

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