1、CT引导下125I粒子植入治疗胸壁复发或转移性肿瘤探讨与实践 The Investigation of CT-guided implantation of 125I seeds for chest wall metastasis or recurrence,Ping Jiang, Junjie Wang 23-May- 2012,背景 Background(1),Kyobu Geka. 2011 Jul;64(8 Suppl):725-32,J Thorac Cardiovasc Surg 2007;133(1):10410,背景 Background(2),J Clin Oncol 200
2、8; 26:5113-5118,Int J Radiat Oncol Biol Phys 2008; 70:477-484,背景 Background(3),治疗 treatment,手术surgery,放疗radiotherapy,无法手术unresectable,复发relapse,再复发re-relapse,有效control,背景 Background(4),目的 Objective,评价125I粒子植入治疗胸壁复发或转移性肿瘤的可行性、有效性及安全性。To evaluate the feasibility, efficacy and morbidity of implantation
3、 of 125 I seeds for refractory chest wall matastasis or recurrence.,材料与方法 Methods & materials,材料与方法 Methods & materials,患者一般情况 （Characteristics of patients）（n =20),材料与方法 Methods & materials,材料与方法 Methods & materials,患者一般情况 （Characteristics of patients）（n =20),患者一般情况 （Characteristics of patients）（n =
4、20),材料与方法 Methods & materials,材料与方法 Methods & materials,术前计划 pretreatment planning: PTV=GTV+0.5cm,材料与方法 Methods & materials,粒子植入技术 Seeds implantation technique: 粒子距离皮缘2cmavoid severe skin reaction by placing the seeds at a distance of 2 cm away from marginal skin,材料与方法 Methods & materials,术后剂量验证post
5、implant dosimetry evaluation:,材料与方法 Methods & materials,材料与方法 Methods & materials,结果 Results (1) (局部疗效 local position,RECIST version 1.1),结果 Results (2),结果 Results (3) (KaplanMeier method SPSS 13.0),结果 Results (4),结果 Results (4),结果 Results (5),毒副反应Side effects of 125 I seeds implantation (RTOG),讨论 D
6、iscussion (1),手术 Surgery 围手术期死亡率0 to 4.5% Risk of perioperative mortality from 0 to 4.5%Hemmati et al, 79 chest wall metastasectomy ,5-y overall survival 40%,Eur J Cardio thorac Surg(2011),讨论 Discussion (2),手术Surgery,European Journal of Cardio-thoracic Surgery 19(2001)584588,Ann Thorac Surg 2005;80:
7、203240,讨论 Discussion (3),再程放疗 Re-irradiation,讨论 Discussion (4),Int. J. Radiation Oncology Biol. Phys, 2008; 70:477-484,Int. J. Radiation Oncology Biol. Phys., 2011,Int J Clin Oncol 2004; 9:179-183,结论 Conclusion,CT引导下125I粒子植入治疗胸壁复发或转移性肿瘤是可行的放射治疗手段之一。CT guided implantation of 125 I seeds for chest wall matastasis or recurrence is feasible ,and is one of the promising modalities of radiotherapy.,谢 谢,
