1、Te , o, V,50 =,:13088715500 3 C 5 d !#8 db L王燕萍,张虹 ( vBD, 730000)K1 “:研制维生素C微囊并制成缓释片剂,评价其体外释放特性。ZE:采用溶剂- 非溶剂法制备维生素C微囊,制成缓释片剂,采用紫外分光光度法测定其载药量,采用转篮法测定体外释放特性。T:维生素C缓释片剂,可控制药物释放。 :该方法工艺简单,可靠,有实用价值。1oM 维生素C;微囊;缓释片剂;体外释放度ms | R965 DS M A cI| 1001-5213(2005)11-1023-02Studyonpreparation ofvitaminCsustained-
2、releasetabletsanddetermination ofin vitro releaserateWANG Yan-ping, ZHANG Hong(TheFirst Affiliated Hospitolof Lanzhou University, Gangsu Lanzhou 730000,China)ABSTRACT:OBJECTIVE To preparevitaminC sustained-releasetablets anddeterminetheir in vitro releaserate.METHODS Usesolvent-non-methods toprepare
3、vitaminC sustained-releasetablets,UV methodwasusedtodetermineitscontentand the invitro re-lease ratewasdetermined by rotate basket method.RESULTS Vitamin C sustained-release tablets could control release of drug.CONCLUSION Themethod issimple,reliableandpractical.KEYWORDS:vitaminC;microspheres;sustai
4、ned-releasetablets;in vitro release rate 3 C,s F ,8 =V, |%? 8,y7h %5c。 LYV 3 C 57! d 4r e0 db,0i,h 0Q ,0 Q “。1 N 1.1 3 Cv (S0 3 _ , |100425-200301); 3 C( Z 0 );Y8 ( Z k4=,0); k4 (sB。1.2 N 751-GD, Vns;9( ZsN );XSZ - 107;A( ao;N); ? db kN(?vN );78X-24 N( ZZ0_N );AL2040? ( V + )。2 ZET2.1 3 C 5! 4-d 4E。
5、 | 3 C 0.2 g,%!。 |Y8 0.8 g ,F =JA: | k“j ,4600 5, 5 , ( s ,s z, ZE 。TnV1。V1 5 # sTTab 1 The results of particle diameter of vitamin C micro-spheres| 5 5 /m97050501 570 40.610.197051201 550 43.58.397051202 600 40.516.22.3 3 C d 4! | 3 C 5(M 3 C 100 g) a ,xF500 g,V3| , , , 0.5 g,。2.4 5# d 4 3 Cc 2.4.
6、1 L1“ I | 3 Cv ,F EA(9 1000 )sY 1.0 ,2.5, 5.0,7.5,10.0 mg L- 1 A, EA b,245 nm) l 1 , l:US, iUS,S wL:A =0.071 0C- 0.014 3 r =0. 999 8,V 3 C1. 0 10.0 mg L- 1S = zL1“。2.4. 2 l q k F“ lE。 |X 3Cc 3 C d ( |97050501)10 , ,%, 。 |25 mg,F 3Cv A,v2.4. 3/ZE , ,9 。TnV2。2.4. 3 5 3 C0 # d 3 Cc | 3 C 5# d sY%、1023
7、SD02005 M25 11 Chin Hosp Pharm J, 2005 Nov,Vol 25,No.11V2 F“ l kVTab 2 Recoveryof vitamin CI|“/g“ c /mgF /mg9 /mg l q/% ( l q/% RSD/%1 0.025 1 5.059 1.890 6.967 100.952 0.024 8 5.000 1.890 6.904 100.743 0.026 9 5.422 3.780 9.142 98.41 100.05 1.034 0.025 7 5.180 3.780 8.949 99.715 0.023 9 4.817 3.780
8、 8.614 100.45 , |25 mg, EA , 100 mL,( 。 |1mL, d10mL,( , EAb,245 nm) l, S wL,9 , 5# d 3 Cc ,TnV3,V4。V3 5 3 C0 (n=3)Tab 3 Thedrug-loadinginvitamin C microspheres(n=3)| 3 Cc /% RSD/%97050501 27.1 1.897051201 28.0 0.997051202 31.4 1.2V4 d 3 Cc (n=3)Tab 4 Thecontent in vitaminC sustained-releasetablets(n
9、=3)| 3 Cc MS U /% RSD/%97050501 101.0 0.797051201 98.6 1.197051202 99.8 1.32.5 3 C 5# d 0 db2.5. 1 3 C 5 db E2 。 | 3 C 510 mg,i, EA db,(37.00.5), 50 r min-1 ,sY0. 5,1, 1.5,2 ,4,8 ,10, 12 h | db A5 mL( H db), d r (0. 45 m)Vr, db b,245 nm) l,9, 5 dbs q(n=6)。Tnm1。2. 5. 2 3 C d db m1 dbs q- HWmFig 1 Acc
10、umulativereleaseprofilein vitroE2 ,| 3 C d , EA db,(37.0 0. 5), 100 r min- 1 ,sY0.5,1,1. 5,2 ,4 ,8,10,12 h | db A5 mL( H db), d r (0.45 m)V r, db b,245 nm) l,9 ,d dbs q(n =6)。Tnm1。3 ) ! 5 H, P 4Kz5bQ 12h,“ 4 “。F -H,bF , V PY8 5 s。 L 5s0 Y8, s0cY48%,z, 、d=?, 4。+ 5 5C db0Q /: Y8 :0830-2587993, 1388273
11、6092;E-mail: b R %y0T李晓冰,李万平,肖顺汉,李华,陈美娟,李亮 (D0 i, +646000)K1 “:观察肝毒清颗粒对急性肝损伤的保护作用。ZE:选用WISTER大鼠60只,随机分为6组,即空白对照组、模型组、肝毒清颗粒大、中、小剂量组,乙肝宁阳性对照组。用硫代乙酰胺复制急性肝损伤模型。检测血清肿瘤坏死因子(TNF-)、白介素-6(IL-6)水平。T:硫代乙酰胺急性肝损伤时,肝毒清颗粒能使血清TNF-、IL-6水平明显降低,与模型组比较,差异有显著性(P0.05)。 :肝毒清颗粒能减少致炎细胞因子的生成,减轻致炎细胞因子的肝损害,对肝脏起到保护作用。1oM 肝毒清;大鼠
12、;肝损伤;细胞因子ms | R285.5 DS M A cI| 1001-5213(2005)11-1024-03Thesdutyonadjustingeffecton cytokines ofGanduqinggranulesLI Xiao-bing, LI Wan-ping,XIAO Shun-han, LI Hua,CHEN Mei-juan,LI Liang(Department of Pharmacology ofLuzhouMedicalCollege,Sichuan Luzhou 646000, China)ABSTRACT:OBJECTIVE To observetheprotectiveeffect of Ganduqinggranules(GDQ) onacutehepaticinjury.METHODS Sixty1024 SD02005 M25 11 Chin Hosp Pharm J, 2005 Nov,Vol 25,No.11
